Polysaccharides obtained from cordyceps militaris alleviate hyperglycemia by regulating gut microbiota in mice fed a high-fat/sucrose diet

Bao Hong Lee, Chia Hsiu Chen, Yi Yun Hsu, Pei Ting Chuang, Ming Kuei Shih, Wei Hsuan Hsu

研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)

摘要

Polysaccharides isolated from fungus Cordyceps militaris display multi-biofunctions, such as immunostimulation, down-regulation of hyperlipidemia, and anti-cancer function. The occurrence of obesity and metabolic syndrome is related to the imbalance of gut microbiota. In this study, the effects of C. militaris and its fractions on modifying metabolic syndrome in mice were evaluated. Mice were fed a high-fat/high-sucrose diet (HFSD) for 14 weeks to induce body weight increase and hyperlipidemia symptoms in mice, and then the mice were simultaneously given a HFSD and C. militaris samples for a further 8 weeks. The results indicated that the fruit body, polysaccharides, and cordycepin obtained from C. militaris had different efficacies on regulating metabolic syndrome and gut microbiota in HFSD-treated mice. Polysaccharides derived from C. militaris decreased the levels of blood sugar and serum lipids in mice fed HFSD. In addition, C. militaris-polysaccharide treatment obviously improved intestinal dysbiosis through promoting the population of next generation probiotic Akkermansia muciniphila in the gut of mice fed HFSD. In conclusion, polysaccharides derived from C. militaris have the potential to act as dietary supplements and health food products for modifying the gut microbiota to improve the metabolic syndrome.

原文English
文章編號1870
期刊Foods
10
發行號8
DOIs
出版狀態Published - 2021 8月

All Science Journal Classification (ASJC) codes

  • 食品科學
  • 微生物學
  • 健康(社會科學)
  • 健康職業(雜項)
  • 植物科學

指紋

深入研究「Polysaccharides obtained from cordyceps militaris alleviate hyperglycemia by regulating gut microbiota in mice fed a high-fat/sucrose diet」主題。共同形成了獨特的指紋。

引用此