Porcine hematopoietic progenitor cell transplantation in nonhuman primates: A review of progress

Yan Lin Tseng, David H. Sachs, David K.C. Cooper

研究成果: Review article同行評審

48 引文 斯高帕斯(Scopus)

摘要

The critical shortage of human donor organs for transplantation would be overcome if a suitable animal, e.g., the pig, could be used as an organ source. There are, however, several immune barriers that have to date resulted in limited function of pig organs transplanted into nonhuman primates. It would be beneficial, and indeed may be essential, to induce a state of tolerance in the primate recipient to the pig organ. In allotransplantation, the successful transplantation of hematopoietic progenitor cells with the development of mixed chimerism is associated with the induction of tolerance toward a donor-specific organ. For some years, this approach has been explored in the pig-to-nonhuman primate model. This experience is briefly reviewed. The problems of natural and elicited anti-pig antibodies, recipient platelet adhesion to pig hematopietic progenitor cells, and the rapid removal of these cells by the host macrophage-phagocytic system are highlighted. Recent experience with the use of hematopoietic cells from pigs homozygous for α1,3-galactosyltransferase gene-knockout is reported.

原文English
頁(從 - 到)1-9
頁數9
期刊Transplantation
79
發行號1
DOIs
出版狀態Published - 2005 1月 15

All Science Journal Classification (ASJC) codes

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