Porous alginate/HAp sponges for bone tissue engineering

Hong Ru Lin, Yu Jen Yeh, Chun Jung Kuo, C. Y. Yang

研究成果: Conference article同行評審

8 引文 斯高帕斯(Scopus)

摘要

This paper describes the preparation and characterization of a three-dimensional, porous sponges made from alginate. The alginate solution was mixed with hydroxylapatite(HAp) to increase its mechanical properties and biocompatibility. The sponge was prepared by a three-step procedure: first gelation of the alginate solution to form a hydrogel with bivalent cations (such as Ca2+, Sr2+ and Ba2+), then freezing, and finally drying by lyophilization to produce a three-dimensional, porous sponge. The effects of quenching temperature, type and concentration of crossing linking agents on the structure and properties of scaffolds were investigated. The results demonstrate that the porous sponges not only have well interconnected pore structure, but also have well mechanical properties. In order to examine its biocompatibility, rat osteogenic sarcoma cell line (OGS) was seeded into the scaffolds. Using alginate sponges that serve as a template for tissue engineering has a potential use in the regeneration of bone tissue.

原文English
頁(從 - 到)3043-3048
頁數6
期刊Materials Science Forum
426-432
發行號4
DOIs
出版狀態Published - 2003
事件Thermec 2003 Processing and Manufacturing of Advanced Materials - Madrid, Spain
持續時間: 2003 7月 72003 7月 11

All Science Journal Classification (ASJC) codes

  • 一般材料科學
  • 凝聚態物理學
  • 材料力學
  • 機械工業

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