Positive symptoms in antipsychotic-naïve schizophrenia are associated with increased body mass index after treatment

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Objective: Weight gain is an important risk factor for morbidity and mortality among patients with schizophrenia. We speculated that positive symptoms, related to dopaminergic hyperactivity and altered mesolimbic function, are associated with weight gain. Methods: Twenty-two antipsychotic-naïve, first-episode patients with schizophrenia were enrolled. The Positive and Negative Syndrome Scale was completed at enrollment and follow-up. Body mass index (BMI) was also measured. Results: The increase in BMI, after 6.04 ± 2.16 years of follow-up, was associated with positive symptoms, but not negative symptoms, before treatment with antipsychotics in antipsychotic-naïve patients with schizophrenia. Conclusion: This finding implied that dopaminergic hyperactivity could be an important factor to predict the treatment outcome. Body weight control is important for the health management of patients with schizophrenia with more severe positive symptoms.

原文English
頁(從 - 到)155-159
頁數5
期刊Clinical Psychopharmacology and Neuroscience
19
發行號1
DOIs
出版狀態Published - 2021 2月

All Science Journal Classification (ASJC) codes

  • 精神病學和心理健康
  • 行為神經科學
  • 藥學(醫學)

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