Post-coital vaginal douching is risky for non-regression of low-grade squamous intraepithelial lesion of the cervix

Tang Yuan Chu, Chao Agnes Hsiung, Chi An Chen, Hung Hsueh Chou, Chih Ming Ho, Tsai Yen Chien, Hui Ju Chang, Cheng Yang Chou, Jui Der Liou, Yuen Yee Kan, Chang Yao Hsieh

研究成果: Article

8 引文 斯高帕斯(Scopus)

摘要

Background: Vaginal douching is a common practice worldwide. Its effect on the natural history of the early lesion of human papillomavirus (HPV) infection, low-grade squamous intraepithelial lesion (LSIL), is unknown. Methods: In a prospective nation-wide cohort (n = 1332), epidemiological variables including habit of vaginal douching after intercourse and outcomes of LSIL were studied. Colposcopy-confirmed LSIL women (n = 295) were followed every 3 months. Parameters of HPV infection, sexual behavior, personal hygiene and environmental exposures were compared with the follow-up outcomes. Results: There was a 15% chance of HSIL co-existing with the LSIL cytology result. Eight percent of colposcopy-confirmed LSIL were found with HSIL in 1 year. With a follow-up of up to 36 months, 83% LSIL regressed, 11% progressed and 6% persisted. The mean time (95% CIs) to regression and progression were 5.2 (4.7-5.8) and 8.0 (5.8-10.3) months, respectively. Risk factors of the non-regression of LSIL included HPV prevalence on enrollment, habit of vaginal douching after intercourse with a hygiene product and non-regular Pap screening, with odd ratio of 4.4 (1.9-10.3), 3.14 (1.04-9.49) and 2.12 (1.24-3.62), respectively. HPV prevalence and vaginal douching also conferred a slower regression of LSIL (8.0 vs. 4.1 months, P < .001 and 8.0 vs. 5.6 months, P = 0.02, respectively). Conclusion: The study disclosed a transient but warning nature of cytological LSIL. Practicing of vaginal douching after intercourse, especially with hygiene products, is associated with non-regression of LSIL.

原文English
頁(從 - 到)449-453
頁數5
期刊Gynecologic oncology
120
發行號3
DOIs
出版狀態Published - 2011 三月

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

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