@article{be808f27640d4638a376ccc0ff315603,
title = "Potential of Autologous Progenitor Cells and Decellularized Porcine Artery Matrix in Construction of Tissue-engineered Vascular Grafts",
abstract = "To develop a tissue-engineered vascular graft, we used pericardial effusion-derived progenitor cells (PEPCs) collected from drained fluid after open-heart surgery in children with congenital heart diseases to repopulate a decellularized porcine pulmonary artery. The PEPCs were compared with human fibroblasts (HS68) and human umbilical vein endothelial cells (HUVECs) in cell growth and migration. They were cultured with the matrices via an inner approach (intima), lateral approach (media), and outer approach (adventitia). PEPCs grew and migrated better than the other two cells 14 days after seeding in the decellularized vessel. In immunofluorescence assays, PEPCs expressed CD90 and CD105 indicating a vascular differentiation. PEPCs grew in a decellularized porcine pulmonary artery matrix may have the potential for producing tissue-engineered vascular grafts.",
author = "Wang, {Jieh Neng} and Kan, {Chung Dann} and Lin, {Shao Hsien} and Chang, {Ko Chi} and Stephanie Tsao and Wong, {Tak Wah}",
note = "Funding Information: The authors would like to acknowledge technical support from Ms. Ya-Li Hsiao. This work was supported by Ministry of Science and Technology, Taiwan MOST-103-2314-B-006-077, MOST-110-2314-B-006-048-MY2 and National Cheng Kung University Hospital NCKUH-10506007 to JNW. TWW acknowledges funding from MOST-109-2327-B-006-005, NCKUH-1106018, and the Center of Applied Nanomedicine, National Cheng Kung University from the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. Publisher Copyright: {\textcopyright} 2021 Taylor & Francis Group, LLC.",
year = "2021",
doi = "10.1080/15476278.2021.1963603",
language = "English",
volume = "17",
pages = "72--84",
journal = "Organogenesis",
issn = "1547-6278",
publisher = "Landes Bioscience",
number = "3-4",
}