Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons

Chiung Chun Huang; Chih Hung Lin; Po Wu Gean

doi:10.1016/S0304-3940(98)00571-0

Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons

Chiung Chun Huang, Chih Hung Lin, Po Wu Gean

藥理學科暨藥理學研究所

研究成果: Article › 同行評審

18 引文斯高帕斯（Scopus）

摘要

Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.

原文	English
頁（從 - 到）	9-12
頁數	4
期刊	Neuroscience Letters
卷	253
發行號	1
DOIs	https://doi.org/10.1016/S0304-3940(98)00571-0
出版狀態	Published - 1998 8月 28

All Science Journal Classification (ASJC) codes

神經科學 (全部)

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10.1016/S0304-3940(98)00571-0

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abstract = "Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.",

author = "Huang, {Chiung Chun} and Lin, {Chih Hung} and Gean, {Po Wu}",

note = "Funding Information: This study was supported by the National Science Council of Taiwan grant NSC86-2314-B006-002-M10.",

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AU - Gean, Po Wu

N1 - Funding Information: This study was supported by the National Science Council of Taiwan grant NSC86-2314-B006-002-M10.

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Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons

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