摘要
The purpose of this paper is to develop a formula for calculating the required sample size for paired recurrent events data. The developed formula is based on robust non-parametric tests for comparing the marginal mean function of events between paired samples. This calculation can accommodate the associations among a sequence of paired recurrent event times with a specification of correlated gamma frailty variables for a proportional intensity model. We evaluate the performance of the proposed method with comprehensive simulations including the impacts of paired correlations, homogeneous or nonhomogeneous processes, marginal hazard rates, censoring rate, accrual and follow-up times, as well as the sensitivity analysis for the assumption of the frailty distribution. The use of the formula is also demonstrated using a premature infant study from the neonatal intensive care unit of a tertiary center in southern Taiwan.
原文 | English |
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頁(從 - 到) | 1823-1838 |
頁數 | 16 |
期刊 | Statistics in Medicine |
卷 | 36 |
發行號 | 11 |
DOIs | |
出版狀態 | Published - 2017 5月 20 |
All Science Journal Classification (ASJC) codes
- 流行病學
- 統計與概率