Predicted risk of childhood allergy, asthma, and reported symptoms using measured phthalate exposure in dust and urine

N. Y. Hsu, C. C. Lee, J. Y. Wang, Y. C. Li, H. W. Chang, C. Y. Chen, C. G. Bornehag, P. C. Wu, J. Sundell, H. J. Su

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143 引文 斯高帕斯(Scopus)

摘要

The associated risk of phthalate exposure, both parent compounds in the home and their metabolites in urine, to childhood allergic and respiratory morbidity, after adjusting for exposures of indoor pollutants, especially bioaerosols, was comprehensively assessed. Levels of five phthalates in settled dust from the homes of 101 children (3-9years old) were measured, along with their corresponding urinary metabolites. Other environmental risk factors, including indoor CO 2, PM 2.5, formaldehyde, 1,3-β-d-glucan, endotoxin, allergen and fungal levels, were concomitantly examined. Subject's health status was verified by pediatricians, and parents recorded observed daily symptoms of their children for the week that the home investigation visit took place. Significantly increased level of benzylbutyl phthalate, in settled dust, was associated with test case subjects (allergic or asthmatic children). Higher levels of dibutyl phthalate and its metabolites, mono-n-butyl phthalate, and mono-2-ethylhexyl phthalate were found to be the potential risk factors for the health outcomes of interest. Similarly, indoor fungal exposure remained a significant risk factor, especially for reported respiratory symptoms. The relative contribution from exposure to phthalates and indoor biocontaminants in childhood allergic and respiratory morbidity is, for the first time, quantitatively assessed and characterized.

原文English
頁(從 - 到)186-199
頁數14
期刊Indoor Air
22
發行號3
DOIs
出版狀態Published - 2012 六月

All Science Journal Classification (ASJC) codes

  • 環境工程
  • 建築與營造
  • 公共衛生、環境和職業健康

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