TY - JOUR
T1 - Premarin improves outcomes of spinal cord injury in male rats through stimulating both angiogenesis and neurogenesis
AU - Chen, Sheng Hsien
AU - Yeh, Chao Hung
AU - Lin, Mike Yang Sheng
AU - Kang, Chieh Yi
AU - Chu, Chin Chen
AU - Chang, Fong Ming
AU - Wang, Jhi Joung
PY - 2010/10
Y1 - 2010/10
N2 - Objective: To ascertain whether Premarin improves spinal cord injury outcomes in male rats by stimulating both angiogenesis and neurogenesis. Design: Chi Mei Medical Center research laboratory. Subjects: Male Sprague-Dawley rats 240-258 g. Interventions: Anesthetized rats, after the onset of spinal cord injury, were divided into two groups and given the vehicle solution (1 mL/kg of body weight) or Premarin (1 mg/kg of body weight). Saline or Premarin solutions were administered intravenously and immediately after spinal cord injury. Measurements and main results: Premarin (an estrogen sulfate) causes attenuation of spinal cord injury-induced spinal cord infarction and hind limb locomotor dysfunction. Spinal cord injury-induced apoptosis as well as activated inflammation was also significantly Premarin-reduced. In injured spinal cord, angiogenesis, neurogenesis, and production of an antiinflammatory cytokine were all Premarin therapy-promoted. Conclusions: Our results indicate that Premarin therapy may protect against spinal cord apoptosis after spinal cord injury through mechanisms stimulating both angiogenesis and neurogenesis in male rats.
AB - Objective: To ascertain whether Premarin improves spinal cord injury outcomes in male rats by stimulating both angiogenesis and neurogenesis. Design: Chi Mei Medical Center research laboratory. Subjects: Male Sprague-Dawley rats 240-258 g. Interventions: Anesthetized rats, after the onset of spinal cord injury, were divided into two groups and given the vehicle solution (1 mL/kg of body weight) or Premarin (1 mg/kg of body weight). Saline or Premarin solutions were administered intravenously and immediately after spinal cord injury. Measurements and main results: Premarin (an estrogen sulfate) causes attenuation of spinal cord injury-induced spinal cord infarction and hind limb locomotor dysfunction. Spinal cord injury-induced apoptosis as well as activated inflammation was also significantly Premarin-reduced. In injured spinal cord, angiogenesis, neurogenesis, and production of an antiinflammatory cytokine were all Premarin therapy-promoted. Conclusions: Our results indicate that Premarin therapy may protect against spinal cord apoptosis after spinal cord injury through mechanisms stimulating both angiogenesis and neurogenesis in male rats.
UR - http://www.scopus.com/inward/record.url?scp=77957238172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957238172&partnerID=8YFLogxK
U2 - 10.1097/CCM.0b013e3181ef44dc
DO - 10.1097/CCM.0b013e3181ef44dc
M3 - Article
C2 - 20657272
AN - SCOPUS:77957238172
SN - 0090-3493
VL - 38
SP - 2043
EP - 2051
JO - Critical care medicine
JF - Critical care medicine
IS - 10
ER -