Preparation of a novel molecularly imprinted polymer by the sol-gel process for sensing creatinine

Ta Jen Li, Po Yen Chen, Po Chin Nien, Chia Yu Lin, R. Vittal, Tzong Rong Ling, Kuo Chuan Ho

研究成果: Article同行評審

40 引文 斯高帕斯(Scopus)

摘要

A novel molecularly imprinted polymer (MIP) was prepared and used as an artificial receptor for creatinine (Cre). A sol-gel process was used to prepare the MIP. Tetraethoxysilane (TEOS) was employed as the crosslinker for the formation of a silica matrix for the MIP. Aluminum ion (Al 3+) was chosen as the dopant to generate Lewis acid sites in the silica matrix for interactions with Cre. Through the sol-gel process, a polymeric matrix with memory sites for Cre was obtained, and this is mentioned here as the molecularly imprinted polymer for creatinine (MIP Cre). The imprinting efficiency of MIP Cre was evaluated by contrasting the adsorbed amount of Cre by MIP Cre with that by the corresponding non-imprinted polymer (NIP). Creatine (Cn), N-hydroxysuccinimide (NHS), and l-tyrosine (l-tyr) were selected as interferences to study the selectivity of the MIP Cre. The interference studies were also conducted using binary mixtures, such as Cre/Cn, Cre/NHS, and Cre/l-tyr. All these studies reveal that the MIP Cre possess a remarkable affinity for Cre. The crucial role of Al 3+ in this system is discussed in detail. Furthermore, the effects of concentrations of Al 3+ and TEOS on the adsorbed amount of Cre by MIP Cre were also investigated.

原文English
頁(從 - 到)83-90
頁數8
期刊Analytica Chimica Acta
711
DOIs
出版狀態Published - 2012 1月 20

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 生物化學
  • 環境化學
  • 光譜

指紋

深入研究「Preparation of a novel molecularly imprinted polymer by the sol-gel process for sensing creatinine」主題。共同形成了獨特的指紋。

引用此