Preparation of secolycorines against acetylcholinesterase

Shoei Sheng Lee, Uppala Venkatesham, Chitneni Prasad Rao, Sio Hong Lam, Jung Hsin Lin

研究成果: Article同行評審

40 引文 斯高帕斯(Scopus)

摘要

5,6-Secolycorines possessing a 5,6-dihydrophenanthridine skeleton were facilely prepared from lycorine through chemical transformations, mainly including N-alkylation, Hofmann degradation type reaction, reductive cleavage of trichloroethylcarbonyl moiety, and hydrogenation. Several secolycorine derivatives showed potent inhibitory activity against acetylcholinesterase with the IC50 value at micromolar range and are more potent than galanthamine.

原文English
頁(從 - 到)1034-1043
頁數10
期刊Bioorganic and Medicinal Chemistry
15
發行號2
DOIs
出版狀態Published - 2007 一月 15

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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