TY - JOUR
T1 - Preparation of secolycorines against acetylcholinesterase
AU - Lee, Shoei Sheng
AU - Venkatesham, Uppala
AU - Rao, Chitneni Prasad
AU - Lam, Sio Hong
AU - Lin, Jung Hsin
N1 - Funding Information:
We gratefully acknowledge the financial support from the National Science Council (NSC), Taiwan, ROC under Grant NSC92-2320-B-002-079, and the Ministry of Economics, Taiwan, ROC under Grant 93-EC-17-A-20-S1-0010.
PY - 2007/1/15
Y1 - 2007/1/15
N2 - 5,6-Secolycorines possessing a 5,6-dihydrophenanthridine skeleton were facilely prepared from lycorine through chemical transformations, mainly including N-alkylation, Hofmann degradation type reaction, reductive cleavage of trichloroethylcarbonyl moiety, and hydrogenation. Several secolycorine derivatives showed potent inhibitory activity against acetylcholinesterase with the IC50 value at micromolar range and are more potent than galanthamine.
AB - 5,6-Secolycorines possessing a 5,6-dihydrophenanthridine skeleton were facilely prepared from lycorine through chemical transformations, mainly including N-alkylation, Hofmann degradation type reaction, reductive cleavage of trichloroethylcarbonyl moiety, and hydrogenation. Several secolycorine derivatives showed potent inhibitory activity against acetylcholinesterase with the IC50 value at micromolar range and are more potent than galanthamine.
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U2 - 10.1016/j.bmc.2006.10.026
DO - 10.1016/j.bmc.2006.10.026
M3 - Article
C2 - 17085051
AN - SCOPUS:33845325215
SN - 0968-0896
VL - 15
SP - 1034
EP - 1043
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 2
ER -