Preparation of shell crosslinked nanoencapsulate for drug carriers by using poly(N-isopropyl acrylamide)-co-poly(L-lysine) grafted copolymer

You Liang Tu, Cheng Chien Wang, Chuh Yung Chen

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Shell crosslinked nanoencapsulate were prepared via crosslinking reaction between double hydrophilic grafted copolymers poly(N-isopropyl acrylamide)-co-poly(L-lysine) (PNIPAm-co-PLLys) and natural crosslinking agent genipin. These shell crosslinked nanoencapsulate possess spherical structures and the hydrodynamic radiuses are about 18.5 nm to 37.7 nm. Drug-loaded shell crosslinked nanoencapsulate were applied as drug carriers. Model drug methotrexate (MTX) were loaded into polymeric nanoencapsulate with different loading ratios (polymer / MTX = 10 / 0.5 and 10 / 1.0), then crosslinking agent genipin was added into micelle solution to form drug-loaded shell crosslinked nanoencapsulate. Entrapment efficiency and drug loading content of the drug-loaded shell crosslinked nanoencapsulate are about 12.66 wt% to 20.1 wt% and 0.84 wt% to 1.28 wt%, respectively. In-vitro drug release experiments of drug-loaded shell crosslinked nanoencapsulate were carried out in pH 7.4 phosphate buffer solution at 37 °C. All of these samples possess burst release in initial 8 h, and final accumulate MTX release amounts are about 71% to 97%.

原文English
文章編號134
期刊Journal of Polymer Research
25
發行號6
DOIs
出版狀態Published - 2018 六月 1

All Science Journal Classification (ASJC) codes

  • 聚合物和塑料
  • 有機化學
  • 材料化學

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