TY - JOUR
T1 - Preparation of type I collagen fibrillar matrices and the effects of collagen concentration on fibroblast contraction
AU - Huang, Lynn Ling-Huei
AU - Nimni, Marcel E.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Collagen which is predominant in the extracellular matrix, serves as a support for the connective tissues. It, and its derived matrices have been used as bioprostheses for burn wound dressings and tissues templates due to their biocompatibility. Since collagen can be present in different forms, to evaluate and standardize experimental models, collagen fibrillar matrices (CFM) were reconstituted as native type collagen fibrils from purified pepsin soluble type I collagen. The in vitro CFM contraction model developed allowed us to study the effects of the concentration of collagen on CFM contraction by fibroblasts.
AB - Collagen which is predominant in the extracellular matrix, serves as a support for the connective tissues. It, and its derived matrices have been used as bioprostheses for burn wound dressings and tissues templates due to their biocompatibility. Since collagen can be present in different forms, to evaluate and standardize experimental models, collagen fibrillar matrices (CFM) were reconstituted as native type collagen fibrils from purified pepsin soluble type I collagen. The in vitro CFM contraction model developed allowed us to study the effects of the concentration of collagen on CFM contraction by fibroblasts.
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M3 - Article
AN - SCOPUS:0027678696
SN - 1016-2356
VL - 5
SP - 664
EP - 675
JO - Biomedical Engineering - Applications, Basis and Communications
JF - Biomedical Engineering - Applications, Basis and Communications
IS - 5
ER -