Presynaptic D2 dopaminergic receptors mediate inhibition of excitatory synaptic transmission in rat neostriatum

Kuei Sen Hsu, Chiung Chun Huang, Cheng Hsun Yang, Po Wu Gean

研究成果: Article同行評審

101 引文 斯高帕斯(Scopus)

摘要

The effect of dopamine (DA) on excitatory synaptic transmission was studied in rat neostriatal neurons using intracellular- and whole-cell voltage clamp-recording methods. Depolarizing excitatory postsynaptic potentials (EPSPs) were evoked by cortical stimulation. Superfusion of DA (0.01-10 μM) reversibly decreases EPSP in a concentration-dependent manner and with a estimated IC5 of 0.3 μM. In addition, the inhibitory effect induced by DA at a low concentratiion (0.1 μM) was antagonized by sulpiride (1-10 nM), a selective D2 dopaminergic receptor antagonist. However, D1 dopaminergic receptor antagonist SKF-83566 (1-5 μM) did not affect the blocking effect by DA 0.1 μM. Based on these findings, we conclude that DA at a low concentration (≤ 0.1 μM) reduced the excitatory response of neostriatal neurons following cortical stimulation via the activation of D2, but not D1 dopaminergic receptors, located on the terminals of corticostriatal neurons.

原文English
頁(從 - 到)264-268
頁數5
期刊Brain Research
690
發行號2
DOIs
出版狀態Published - 1995 九月 4

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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