Prevalence and risk factors for colonization by extended-spectrum β-lactamase-producing or ST 131 escherichia coli among asymptomatic adults in community settings in Southern Taiwan

Pin Chieh Wu, Jiun Ling Wang, Po Ren Hsueh, Po Hsiang Lin, Ming Fang Cheng, I. Fei Huang, Yao Shen Chen, Susan Shin Jung Lee, Mar Guang-Yuan, Hsien Chung Yu, Chiao Lin Hsu, Fu Wei Wang, Chi Shen Chen, Chih Hsin Hung, Wen Chien Ko

研究成果: Article

摘要

Purpose: Fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is common in Asia, especially in China and Southeast Asia. There are no data about fecal carriage of ESBL-EC and mcr-1-positive E. coli in Taiwan, and few studies focusing on the risk factors of asymptomatic fecal carriage of epidemic ST131 E. coli have been published. Patients and methods: From healthy inhabitants attending health examinations at a medical center in southern Taiwan in 2017, we collected 724 stool samples, which were examined for ESBL-EC fecal carriage using chromogenic medium. ST131 and mcr1-positive E. coli were also investigated using multiplex PCR. Clinical data from all participating adults were collected to analyze the risk factors for fecal ESBL-EC or ST131 E. coli carriage. Results: The prevalence rate of asymptomatic ESBL-EC fecal carriage in adults was 1.9% (14/724). ST131 was found in 22 (3.0%) adults and mcr-1-positive E. coli was found in three (0.4%) adults. A multivariate analysis showed that the risk factors associated with ESBL-EC carriage were diabetes mellitus (adjusted odds ratio [aOR]: 5.5, 95% confidence interval [CI]: 1.3–22.7), a history of colonic polyps (aOR: 6.4, 95% CI: 1.6–24.9), and chronic renal insufficiency (aOR: 20.7, 95% CI: 1.4–305.7). Underlying cancer (aOR: 4.8, 95% CI: 1.0–22.5) and stroke (aOR: 18.0, 95% CI: 1.6–207.5) were associated with ST131 E. coli fecal carriage. In our cohort, travel to Asian countries and food habit were not associated with ST131 or ESBL-EC fecal carriage. Conclusions: The ESBL-EC or ST131 E. coli fecal carriage rate is low among asymptomatic adults in Taiwan. Certain underlying medical conditions were associated with their fecal carriage.

原文English
頁(從 - 到)1063-1071
頁數9
期刊Infection and Drug Resistance
12
DOIs
出版狀態Published - 2019 一月 1

指紋

Taiwan
Escherichia coli
Odds Ratio
Confidence Intervals
Colonic Polyps
Southeastern Asia
Multiplex Polymerase Chain Reaction
Feeding Behavior
Chronic Renal Insufficiency
China
Diabetes Mellitus
Multivariate Analysis
Stroke
Health
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

引用此文

Wu, Pin Chieh ; Wang, Jiun Ling ; Hsueh, Po Ren ; Lin, Po Hsiang ; Cheng, Ming Fang ; Huang, I. Fei ; Chen, Yao Shen ; Lee, Susan Shin Jung ; Guang-Yuan, Mar ; Yu, Hsien Chung ; Hsu, Chiao Lin ; Wang, Fu Wei ; Chen, Chi Shen ; Hung, Chih Hsin ; Ko, Wen Chien. / Prevalence and risk factors for colonization by extended-spectrum β-lactamase-producing or ST 131 escherichia coli among asymptomatic adults in community settings in Southern Taiwan. 於: Infection and Drug Resistance. 2019 ; 卷 12. 頁 1063-1071.
@article{2dccb33d740e4efdb8d78db182bc0559,
title = "Prevalence and risk factors for colonization by extended-spectrum β-lactamase-producing or ST 131 escherichia coli among asymptomatic adults in community settings in Southern Taiwan",
abstract = "Purpose: Fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is common in Asia, especially in China and Southeast Asia. There are no data about fecal carriage of ESBL-EC and mcr-1-positive E. coli in Taiwan, and few studies focusing on the risk factors of asymptomatic fecal carriage of epidemic ST131 E. coli have been published. Patients and methods: From healthy inhabitants attending health examinations at a medical center in southern Taiwan in 2017, we collected 724 stool samples, which were examined for ESBL-EC fecal carriage using chromogenic medium. ST131 and mcr1-positive E. coli were also investigated using multiplex PCR. Clinical data from all participating adults were collected to analyze the risk factors for fecal ESBL-EC or ST131 E. coli carriage. Results: The prevalence rate of asymptomatic ESBL-EC fecal carriage in adults was 1.9{\%} (14/724). ST131 was found in 22 (3.0{\%}) adults and mcr-1-positive E. coli was found in three (0.4{\%}) adults. A multivariate analysis showed that the risk factors associated with ESBL-EC carriage were diabetes mellitus (adjusted odds ratio [aOR]: 5.5, 95{\%} confidence interval [CI]: 1.3–22.7), a history of colonic polyps (aOR: 6.4, 95{\%} CI: 1.6–24.9), and chronic renal insufficiency (aOR: 20.7, 95{\%} CI: 1.4–305.7). Underlying cancer (aOR: 4.8, 95{\%} CI: 1.0–22.5) and stroke (aOR: 18.0, 95{\%} CI: 1.6–207.5) were associated with ST131 E. coli fecal carriage. In our cohort, travel to Asian countries and food habit were not associated with ST131 or ESBL-EC fecal carriage. Conclusions: The ESBL-EC or ST131 E. coli fecal carriage rate is low among asymptomatic adults in Taiwan. Certain underlying medical conditions were associated with their fecal carriage.",
author = "Wu, {Pin Chieh} and Wang, {Jiun Ling} and Hsueh, {Po Ren} and Lin, {Po Hsiang} and Cheng, {Ming Fang} and Huang, {I. Fei} and Chen, {Yao Shen} and Lee, {Susan Shin Jung} and Mar Guang-Yuan and Yu, {Hsien Chung} and Hsu, {Chiao Lin} and Wang, {Fu Wei} and Chen, {Chi Shen} and Hung, {Chih Hsin} and Ko, {Wen Chien}",
year = "2019",
month = "1",
day = "1",
doi = "10.2147/IDR.S201086",
language = "English",
volume = "12",
pages = "1063--1071",
journal = "Infection and Drug Resistance",
issn = "1178-6973",
publisher = "Dove Medical Press Ltd.",

}

Prevalence and risk factors for colonization by extended-spectrum β-lactamase-producing or ST 131 escherichia coli among asymptomatic adults in community settings in Southern Taiwan. / Wu, Pin Chieh; Wang, Jiun Ling; Hsueh, Po Ren; Lin, Po Hsiang; Cheng, Ming Fang; Huang, I. Fei; Chen, Yao Shen; Lee, Susan Shin Jung; Guang-Yuan, Mar; Yu, Hsien Chung; Hsu, Chiao Lin; Wang, Fu Wei; Chen, Chi Shen; Hung, Chih Hsin; Ko, Wen Chien.

於: Infection and Drug Resistance, 卷 12, 01.01.2019, p. 1063-1071.

研究成果: Article

TY - JOUR

T1 - Prevalence and risk factors for colonization by extended-spectrum β-lactamase-producing or ST 131 escherichia coli among asymptomatic adults in community settings in Southern Taiwan

AU - Wu, Pin Chieh

AU - Wang, Jiun Ling

AU - Hsueh, Po Ren

AU - Lin, Po Hsiang

AU - Cheng, Ming Fang

AU - Huang, I. Fei

AU - Chen, Yao Shen

AU - Lee, Susan Shin Jung

AU - Guang-Yuan, Mar

AU - Yu, Hsien Chung

AU - Hsu, Chiao Lin

AU - Wang, Fu Wei

AU - Chen, Chi Shen

AU - Hung, Chih Hsin

AU - Ko, Wen Chien

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: Fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is common in Asia, especially in China and Southeast Asia. There are no data about fecal carriage of ESBL-EC and mcr-1-positive E. coli in Taiwan, and few studies focusing on the risk factors of asymptomatic fecal carriage of epidemic ST131 E. coli have been published. Patients and methods: From healthy inhabitants attending health examinations at a medical center in southern Taiwan in 2017, we collected 724 stool samples, which were examined for ESBL-EC fecal carriage using chromogenic medium. ST131 and mcr1-positive E. coli were also investigated using multiplex PCR. Clinical data from all participating adults were collected to analyze the risk factors for fecal ESBL-EC or ST131 E. coli carriage. Results: The prevalence rate of asymptomatic ESBL-EC fecal carriage in adults was 1.9% (14/724). ST131 was found in 22 (3.0%) adults and mcr-1-positive E. coli was found in three (0.4%) adults. A multivariate analysis showed that the risk factors associated with ESBL-EC carriage were diabetes mellitus (adjusted odds ratio [aOR]: 5.5, 95% confidence interval [CI]: 1.3–22.7), a history of colonic polyps (aOR: 6.4, 95% CI: 1.6–24.9), and chronic renal insufficiency (aOR: 20.7, 95% CI: 1.4–305.7). Underlying cancer (aOR: 4.8, 95% CI: 1.0–22.5) and stroke (aOR: 18.0, 95% CI: 1.6–207.5) were associated with ST131 E. coli fecal carriage. In our cohort, travel to Asian countries and food habit were not associated with ST131 or ESBL-EC fecal carriage. Conclusions: The ESBL-EC or ST131 E. coli fecal carriage rate is low among asymptomatic adults in Taiwan. Certain underlying medical conditions were associated with their fecal carriage.

AB - Purpose: Fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is common in Asia, especially in China and Southeast Asia. There are no data about fecal carriage of ESBL-EC and mcr-1-positive E. coli in Taiwan, and few studies focusing on the risk factors of asymptomatic fecal carriage of epidemic ST131 E. coli have been published. Patients and methods: From healthy inhabitants attending health examinations at a medical center in southern Taiwan in 2017, we collected 724 stool samples, which were examined for ESBL-EC fecal carriage using chromogenic medium. ST131 and mcr1-positive E. coli were also investigated using multiplex PCR. Clinical data from all participating adults were collected to analyze the risk factors for fecal ESBL-EC or ST131 E. coli carriage. Results: The prevalence rate of asymptomatic ESBL-EC fecal carriage in adults was 1.9% (14/724). ST131 was found in 22 (3.0%) adults and mcr-1-positive E. coli was found in three (0.4%) adults. A multivariate analysis showed that the risk factors associated with ESBL-EC carriage were diabetes mellitus (adjusted odds ratio [aOR]: 5.5, 95% confidence interval [CI]: 1.3–22.7), a history of colonic polyps (aOR: 6.4, 95% CI: 1.6–24.9), and chronic renal insufficiency (aOR: 20.7, 95% CI: 1.4–305.7). Underlying cancer (aOR: 4.8, 95% CI: 1.0–22.5) and stroke (aOR: 18.0, 95% CI: 1.6–207.5) were associated with ST131 E. coli fecal carriage. In our cohort, travel to Asian countries and food habit were not associated with ST131 or ESBL-EC fecal carriage. Conclusions: The ESBL-EC or ST131 E. coli fecal carriage rate is low among asymptomatic adults in Taiwan. Certain underlying medical conditions were associated with their fecal carriage.

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U2 - 10.2147/IDR.S201086

DO - 10.2147/IDR.S201086

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JO - Infection and Drug Resistance

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