Prevalence of extended-spectrum β-lactamases in Proteus mirabilis in a Taiwanese university hospital, 1999 to 2005: identification of a novel CTX-M enzyme (CTX-M-66)

Jiunn Jong Wu, Hung Mo Chen, Wen Chien Ko, Hsiu Mei Wu, Shu Huei Tsai, Jing Jou Yan

研究成果: Article同行評審

13 引文 斯高帕斯(Scopus)

摘要

A total of 1574 nonduplicate Proteus mirabilis isolates collected at a Taiwanese hospital during 1999 to 2005 were analyzed for production of extended-spectrum β-lactamases (ESBLs). Forty-four ESBL-producing isolates including 22 CTX-M-14, 18 CTX-M-3, 2 CTX-M-24, and 2 CTX-M-66 producers were detected, and the proportion of ESBL producers increased from 0.7% in 1999 to approximately 6% after 2002. CTX-M-66 is a novel variant of CTX-M ESBLs that differs from CTX-M-3 by a Ser to Asn change at amino acid position 23. Coresistances to aminoglycosides and ciprofloxacin were very common in the CTX-M-3 producers. The presence of ArmA-type or RmtB-type 16S rRNA methylase that confers high-level aminoglycoside resistance was detected in 12 CTX-M-3 producers and 4 CTX-M-14 producers. Twenty-four clones including an endemic CTX-M-14-producing clone were observed among the 44 ESBL producers by pulsed-field gel electrophoresis, suggesting that both horizontal transfer and clonal spread contributed to the increased prevalence of blaCTX-M in P. mirabilis.

原文English
頁(從 - 到)169-175
頁數7
期刊Diagnostic Microbiology and Infectious Disease
60
發行號2
DOIs
出版狀態Published - 2008 2月

All Science Journal Classification (ASJC) codes

  • 微生物學(醫學)
  • 傳染性疾病

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