Prevalence of human papillomavirus in middle ear carcinoma associated with chronic otitis media

Ying Tai Jin, Sen Tien Tsai, Ching Li, Kong Chao Chang, Jing Jou Yan, Wen Yuan Chao, Hock Liew Eng, Teh Ying Chou, Tzyy Choou Wu, Ih Jen Su

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)


Squamous cell carcinoma of the middle ear (MESCC) is an uncommon tumor and is associated with a history of long-term chronic otitis media (COM) in most cases. Although the human papillomaviruses (HPVs) have been implicated in many human neoplasms, its role in the pathogenesis of MESCC has not been studied. Polymerase chain reaction (PCR) using consensus primers for the detection of HPV types 6, 11, 16, 18, 31, 33, 52b, and 58 was applied in screening fourteen cases of MESCC from archival material. Further subtyping was performed by restriction enzyme digestion of PCR products and by in situ hybridization method on tissue sections. Of the fourteen cases of MESCC, eleven were found to have HPV DNA. HPV-16 was detected in all positive cases. Five cases revealed both HPV-16 and -18. A history of long-term COM (>3years) was found in thirteen of the cases. This is the first report to localize HPV- 16/18 in MESCC on both the tissue level and the molecular level. The high prevalence or HPV in COM-associated MESCC therefore provides a good model to explain the pathogenesis of chronic-inflammation-related human malignancies.

頁(從 - 到)1327-1333
期刊American Journal of Pathology
出版狀態Published - 1997

All Science Journal Classification (ASJC) codes

  • 病理學與法醫學


深入研究「Prevalence of human papillomavirus in middle ear carcinoma associated with chronic otitis media」主題。共同形成了獨特的指紋。