Primary cerebral anaplastic large cell lymphoma containing abundant reactive histiocytes and eosinophils. A case report and literature review

Shih Sung Chuang, Wenya Huang, Ching Nan Lin, Chung Ching Chio, Tsung Chia Tsai, Chin Yang Li, Chia Hui Shen

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)

摘要

Primary cerebral anaplastic large cell lymphoma (ALCL) is very rare. We report on our experience with such a case and review the literature. A 46-year-old Taiwanese woman presented with headache, weakness of her right extremity, and limited eye movement. A solid mass (5 cm × 4 cm) at the left occipital lobe was almost completely removed. The neoplastic cells, some of which had reniform or embryo-like nuclei, were large and were admixed with abundant eosinophils, histiocytes, and some small lymphocytes. These neoplastic cells expressed CD30, CD43, granzyme B and T-cell intracellular antigen-1, but not ALK1, CD3, CD20, CD45, CD79a, cytokeratin, and EMA. They were positive for Epstein-Barr virus-encoded mRNA by in situ hybridization. Polymerase chain reaction study of formalin-fixed tissue showed a clonal gene arrangement of the T-cell receptor-γ chain. ALCL of T-cell lineage with cytotoxic phenotype was diagnosed. The patient received cranial irradiation and has remained with no evidence of disease for 25 months of follow-up.

原文English
頁(從 - 到)647-652
頁數6
期刊Pathology Research and Practice
197
發行號9
DOIs
出版狀態Published - 2001 一月 1

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology

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