Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder-A small-sample SPECT study with [123I]ADAM

Hsin Chun Tsai; Shih Hsien Lin; I. Hui Lee; Po See Chen; Kao Chin Chen; Tzung Lieh Yeh; Wei Jen Yao; Nan Tsing Chiu; Ru Band Lu; Yen Kuang Yang

doi:10.1016/j.psyneuen.2013.06.001

Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder-A small-sample SPECT study with [¹²³I]ADAM

Hsin Chun Tsai, Shih Hsien Lin, I. Hui Lee, Po See Chen, Kao Chin Chen, Tzung Lieh Yeh, Wei Jen Yao, Nan Tsing Chiu, Ru Band Lu, Yen Kuang Yang

研究成果: Article › 同行評審

4 引文斯高帕斯（Scopus）

摘要

The association between hypothalamo-pituitary-adrenal (HPA) axis function and the serotonergic system could be involved in the mechanism of depression. However, neuroimaging evidence is scarce. The aim of the present study was to probe the association between dexamethasone suppression test response and serotonin transporter (SERT) availability in drug-free patients with major depressive disorder (MDD). Seventeen MDD patients (five males and twelve females) were recruited. SPECT with [¹²³I] ADAM was used to measure the midbrain SERT availability, and HPA axis function was measured by the dexamethasone suppression test (DST). The association was significant when considering all participants (ρ=0.69, p=0.002). This association may have clinical implications for the treatment of MDD.

原文	English
頁（從 - 到）	2805-2809
頁數	5
期刊	Psychoneuroendocrinology
卷	38
發行號	11
DOIs	https://doi.org/10.1016/j.psyneuen.2013.06.001
出版狀態	Published - 2013 11月

All Science Journal Classification (ASJC) codes

內分泌學、糖尿病和代謝
內分泌
內分泌和自主系統
精神病學和心理健康
生物精神病學

UN SDG

此研究成果有助於以下永續發展目標

存取文件

10.1016/j.psyneuen.2013.06.001

其它文件與鏈接

引用此

Tsai, H. C., Lin, S. H., Lee, I. H., Chen, P. S., Chen, K. C., Yeh, T. L., Yao, W. J., Chiu, N. T., Lu, R. B., & Yang, Y. K. (2013). Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder-A small-sample SPECT study with [¹²³I]ADAM. Psychoneuroendocrinology, 38(11), 2805-2809. https://doi.org/10.1016/j.psyneuen.2013.06.001

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title = "Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder-A small-sample SPECT study with [123I]ADAM",

abstract = "The association between hypothalamo-pituitary-adrenal (HPA) axis function and the serotonergic system could be involved in the mechanism of depression. However, neuroimaging evidence is scarce. The aim of the present study was to probe the association between dexamethasone suppression test response and serotonin transporter (SERT) availability in drug-free patients with major depressive disorder (MDD). Seventeen MDD patients (five males and twelve females) were recruited. SPECT with [123I] ADAM was used to measure the midbrain SERT availability, and HPA axis function was measured by the dexamethasone suppression test (DST). The association was significant when considering all participants (ρ=0.69, p=0.002). This association may have clinical implications for the treatment of MDD.",

author = "Tsai, {Hsin Chun} and Lin, {Shih Hsien} and Lee, {I. Hui} and Chen, {Po See} and Chen, {Kao Chin} and Yeh, {Tzung Lieh} and Yao, {Wei Jen} and Chiu, {Nan Tsing} and Lu, {Ru Band} and Yang, {Yen Kuang}",

note = "Funding Information: The authors would like to thank the National Science Council of Taiwan ( NSC 93-2314-B-006-107 , NSC 95-2314-B-006-115-MY2 , NSC 97-2314-B-006-006-MY3 ) for their financial support. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. ",

year = "2013",

month = nov,

doi = "10.1016/j.psyneuen.2013.06.001",

language = "English",

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Tsai, HC, Lin, SH, Lee, IH , Chen, PS , Chen, KC, Yeh, TL, Yao, WJ, Chiu, NT, Lu, RB & Yang, YK 2013, 'Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder-A small-sample SPECT study with [¹²³I]ADAM', Psychoneuroendocrinology, 卷 38, 編號 11, 頁 2805-2809. https://doi.org/10.1016/j.psyneuen.2013.06.001

Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder-A small-sample SPECT study with [¹²³I]ADAM. / Tsai, Hsin Chun; Lin, Shih Hsien; Lee, I. Hui 等.
於: Psychoneuroendocrinology, 卷 38, 編號 11, 11.2013, p. 2805-2809.

研究成果: Article › 同行評審

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AU - Tsai, Hsin Chun

AU - Lin, Shih Hsien

AU - Lee, I. Hui

AU - Chen, Po See

AU - Chen, Kao Chin

AU - Yeh, Tzung Lieh

AU - Yao, Wei Jen

AU - Chiu, Nan Tsing

AU - Lu, Ru Band

AU - Yang, Yen Kuang

N1 - Funding Information: The authors would like to thank the National Science Council of Taiwan ( NSC 93-2314-B-006-107 , NSC 95-2314-B-006-115-MY2 , NSC 97-2314-B-006-006-MY3 ) for their financial support. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PY - 2013/11

Y1 - 2013/11

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AB - The association between hypothalamo-pituitary-adrenal (HPA) axis function and the serotonergic system could be involved in the mechanism of depression. However, neuroimaging evidence is scarce. The aim of the present study was to probe the association between dexamethasone suppression test response and serotonin transporter (SERT) availability in drug-free patients with major depressive disorder (MDD). Seventeen MDD patients (five males and twelve females) were recruited. SPECT with [123I] ADAM was used to measure the midbrain SERT availability, and HPA axis function was measured by the dexamethasone suppression test (DST). The association was significant when considering all participants (ρ=0.69, p=0.002). This association may have clinical implications for the treatment of MDD.

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