TY - JOUR
T1 - Profilaggrin, dry skin, and atopic dermatitis risk
T2 - Size matters
AU - McGrath, John A.
PY - 2012/1
Y1 - 2012/1
N2 - Mutations in the FLG gene, which encodes profilaggrin, are known to be a major risk factor for atopic dermatitis as well as other atopic diseases and systemic allergies. New research, however, shows that intragenic copy number variation within FLG also represents an independent risk factor for atopic dermatitis. The new findings indicate that upregulating FLG protein levels by 5-10% may have clinical utility in improving the management of many patients with dry skin and atopy.
AB - Mutations in the FLG gene, which encodes profilaggrin, are known to be a major risk factor for atopic dermatitis as well as other atopic diseases and systemic allergies. New research, however, shows that intragenic copy number variation within FLG also represents an independent risk factor for atopic dermatitis. The new findings indicate that upregulating FLG protein levels by 5-10% may have clinical utility in improving the management of many patients with dry skin and atopy.
UR - http://www.scopus.com/inward/record.url?scp=84856105856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856105856&partnerID=8YFLogxK
U2 - 10.1038/jid.2011.360
DO - 10.1038/jid.2011.360
M3 - Comment/debate
AN - SCOPUS:84856105856
SN - 0022-202X
VL - 132
SP - 10
EP - 11
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 1
ER -