Profiling of influenza viruses by high-throughput carbohydrate membrane array

Weng I. Lao, Ya Fang Wang, Yu Dai Kuo, Chun Hung Lin, Tsung Chain Chang, Ih Jen Su, Jen Ren Wang, Chuan Fa Chang

研究成果: Article同行評審

8 引文 斯高帕斯(Scopus)


Background: Carbohydrate-protein interactions participate in many biological functions. To characterize the binding interactions represents a longstanding challenge. Method: We developed a glycan membrane array to study the interactions of carbohydrates with lectins, proteins and viruses, including 17 lectins, four antibodies (that are specific to different Lewis antigens), one recombinant H5N1 hemagglutinin, and five influenza B clinical isolates. Results: The results were found to be comparable to previous reports, indicating the efficacy and reliability of our developed method. Conclusion: This carbohydrate membrane array represents a convenient, reliable and low-cost method to examine the carbohydrate-binding features of various proteins, high-throughput drug screening and the glycan-binding surveillance of influenza viruses.

頁(從 - 到)283-296
期刊Future Medicinal Chemistry
出版狀態Published - 2011 三月 1

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

指紋 深入研究「Profiling of influenza viruses by high-throughput carbohydrate membrane array」主題。共同形成了獨特的指紋。