Progenitor cells derived from drain waste product of open-heart surgery in children

Tak Wah Wong, Chung Dann Kan, Wen Tai Chiu, Kin Lam Fok, Ye Chun Ruan, Xiaohua Jiang, Junjiang Chen, Chiu Ching Kao, I. Yu Chen, Hui Chun Lin, Chia Hsuan Chou, Chou Wen Lin, Chun Keung Yu, Stephanie Tsao, Yi Ping Lee, Hsiao Chang Chan, Jieh Neng Wang

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Human cardiac progenitor cells isolated from the same host may have advantages over other sources of stem cells. The aim of this study is to establish a new source of human progenitor cells collected from a waste product, pericardiac effusion fluid, after open-heart surgery in children with congenital heart diseases. The fluid was collected every 24 h for 2 days after surgery in 37 children. Mononuclear cells were isolated and expanded in vitro. These pericardial effusion-derived progenitor cells (PEPCs) exhibiting cardiogenic lineage markers, were highly proliferative and enhanced angiogenesis in vitro. Three weeks after stem cell transplantation into the ischemic heart in mice, cardiac ejection fraction was improved significantly without detectable progenitor cells. Gene expression profiles of the repaired hearts revealed activation of several known repair mechanisms including paracrine effects, cell migration, and angiogenesis. These progenitor cells may have the potential for heart regeneration.

原文English
文章編號1028
期刊Journal of Clinical Medicine
8
發行號7
DOIs
出版狀態Published - 2019 7月

All Science Journal Classification (ASJC) codes

  • 一般醫學

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