Prognostic impact of renin-angiotensin system blockade in esophageal squamous cell carcinoma

Yen Hao Chen, Cheng Hua Huang, Hung I. Lu, Chang Han Chen, Wan Ting Huang, Ming Jang Hsieh, Kun Ming Rau, Alice Y.W. Chang, Wei Che Lin, Shau Hsuan Li

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

Introduction: The aim of this study is to evaluate whether the administration of renin-angiotensin system (RAS) inhibitors, angiotensin-I converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), is associated with treatment outcome in patients with esophageal squamous cell carcinoma. Materials and methods: A total of 141 esophageal squamous cell carcinoma patients receiving esophagectomy were identified, and were divided into two groups: an ACEI/ARB group (n=20), and a non-ACEI/ARB group (n=121). The effect of ACEIs or ARBs on cell proliferation and vascular endothelial growth factor (VEGF) secretion of esophageal squamous cell carcinoma cell lines, CE81T/VGH and TE2, were investigated by 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and Enzyme-linked immunosorbent assay (ELISA), respectively. Results: Use of ACEI/ARB (p=0.032), pathologic T stage (p<0.001), pathologic N stage (p=0.012), tumor stage (p=0.006), and tumor location (p=0.032) were significantly associated with superior overall survival. In multivariate comparison, use of ACEI/ARB (p=0.006), tumor stage (p=0.002), and tumor location (p=0.014) represented the independent prognosticators of superior overall survival. In cell lines, ACEIs/ARBs inhibit cell proliferation and VEGF secretion in a dose-dependent manner. Conclusions: ACEIs/ARBs administration is independently associated with superior overall survival in patients with esophageal squamous cell carcinoma receiving esophagectomy. Our data support further investigation of the role of RAS inhibitors as a potential therapy in esophageal squamous cell carcinoma.

原文English
頁(從 - 到)1185-1192
頁數8
期刊JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
16
發行號4
DOIs
出版狀態Published - 2015 十二月 1

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology

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