TY - JOUR
T1 - Proliferative and protective effects of SurR9-C84A on differentiated neural cells
AU - Baratchi, Sara
AU - Kanwar, Rupinder K.
AU - Cheung, Chun Hei Antonio
AU - Kanwar, Jagat R.
N1 - Funding Information:
We are grateful for support from the Institute for Technology Research and Innovation (ITRI), Deakin University.
PY - 2010/10
Y1 - 2010/10
N2 - Targeting survivin has the ability to inhibit apoptosis and regulate mitosis for the protection of neuronal cells, and it offers several advantages for neuronal repair and protection. We found that the BIR motif mutant of survivin (SurR9-C84A) can bind to microtubules and regulate their stability, induce cell division, increase proliferation and activate the expression of cell cycle and neuronal markers in differentiated SK-N-SH and HCN-2 neurons. We further showed the protective effects of SurR9-C84A against post differentiation retinoic acid induced neurotoxicity. These abilities of SurR9-C84A offer a great potential for future neuronal repair therapy.
AB - Targeting survivin has the ability to inhibit apoptosis and regulate mitosis for the protection of neuronal cells, and it offers several advantages for neuronal repair and protection. We found that the BIR motif mutant of survivin (SurR9-C84A) can bind to microtubules and regulate their stability, induce cell division, increase proliferation and activate the expression of cell cycle and neuronal markers in differentiated SK-N-SH and HCN-2 neurons. We further showed the protective effects of SurR9-C84A against post differentiation retinoic acid induced neurotoxicity. These abilities of SurR9-C84A offer a great potential for future neuronal repair therapy.
UR - http://www.scopus.com/inward/record.url?scp=77956648003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956648003&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2010.06.024
DO - 10.1016/j.jneuroim.2010.06.024
M3 - Article
C2 - 20709413
AN - SCOPUS:77956648003
SN - 0165-5728
VL - 227
SP - 120
EP - 132
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -