Prolonged cutaneous analgesia in rats induced by 3-acetylaconitine as an additive

Chi-Fei Wang, Peter Gerner, Birgitta Schmidt, Sho Ya Wang, Ging Kuo Wang

研究成果: Article

2 引文 (Scopus)

摘要

3-Acetylaconitine (3AA) is an "aconitine-like" plant alkaloid that has been used as an analgesic agent for the treatment of chronic pain and rheumatoid arthritis in China. Aconitine-like alkaloids appear to target the CNS for their analgesic action, although they also display local anesthetic properties. We tested whether 3AA prolonged cutaneous analgesia in rats when co-injected with lidocaine (0.5%) and epinephrine (1:200,000), a mixture commonly used in infiltration anesthesia. Inhibition of the cutaneous trunci muscle reflex was evaluated quantitatively by pinpricks applied to the injected area. Co-injection of lidocaine and epinephrine with 3AA ranging within 50-125 μM elicited complete cutaneous analgesia in vivo lasting 3-12 h, and full recovery occurred after ∼5-8 days in a 3AA concentration-dependent manner. In contrast, cutaneous analgesia induced by the mixture of lidocaine and epinephrine or by 3AA alone in rats was significantly shorter. No adverse systemic effects or local toxicities were evident after injection of 3AA as an additive. Our results suggest that "aconitine-like" alkaloids could be exploited as an additive for Jong-lasting cutaneous analgesia.

原文English
頁(從 - 到)83-88
頁數6
期刊Drug Development Research
69
發行號2
DOIs
出版狀態Published - 2008 三月 1

指紋

Analgesia
Aconitine
Skin
Lidocaine
Alkaloids
Epinephrine
Analgesics
Injections
Local Anesthesia
Local Anesthetics
Chronic Pain
Reflex
3-acetylaconitine
China
Rheumatoid Arthritis
Muscles

All Science Journal Classification (ASJC) codes

  • Drug Discovery

引用此文

Wang, Chi-Fei ; Gerner, Peter ; Schmidt, Birgitta ; Wang, Sho Ya ; Wang, Ging Kuo. / Prolonged cutaneous analgesia in rats induced by 3-acetylaconitine as an additive. 於: Drug Development Research. 2008 ; 卷 69, 編號 2. 頁 83-88.
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Prolonged cutaneous analgesia in rats induced by 3-acetylaconitine as an additive. / Wang, Chi-Fei; Gerner, Peter; Schmidt, Birgitta; Wang, Sho Ya; Wang, Ging Kuo.

於: Drug Development Research, 卷 69, 編號 2, 01.03.2008, p. 83-88.

研究成果: Article

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