Propofol does not reduce infarct volume in rats undergoing permanent middle cerebral artery occlusion.

Yu-Chuan Tsai, S. J. Huang, Y. Y. Lai, C. L. Chang, J. T. Cheng

研究成果: Article同行評審

24 引文 斯高帕斯(Scopus)

摘要

As propofol has been reported to have effects similar to those of thiopentone on cerebral blood flow, intracranial pressure and cerebral metabolic rate, we postulated that it might also have a protective effect on focal cerebral ischemia. This experiment was designed to test whether or not propofol can alter infarct volume resulting from permanent focal cerebral ischemia in rats. Forty-five rats were randomly assigned to three groups, all of which received xylaxine (5 mg kg-1 im) and ketamine (100 mg kg-1 ip) anesthesia. Rectal temperatures were controlled at 36-37 degrees C. A right temporal craniotomy was performed and the middle cerebral artery (MCA) was ligated with a 10-O suture. Both common carotid arteries (CCAs) were then occluded for 60 minutes using aneurysm clips. In Group 1 rats (n = 15), normal saline (1 ml kg-1 i.v.) was given right after MCA and CCAs ligation. In Group 2 rats (N = 15), propofol (10 mg kg-1 i.v. bolus) was given right after MCA and CCAs ligation. In Group 3 rats (n = 15), continuous intravenous infusion of propofol (16 mg kg-1 hr-1) was given for four hours following MCA and CCAs ligation, during which time mean arterial pressure was maintained approximately 90 mmHg. Twenty-four hours after ischemia, the brains were removed, frozen, sectioned and stained with 2% 2,3,5-triphenyltetrazolium chloride. The cross-sectional area of infarction on each brain slice was measured using computer imaging analysis.(ABSTRACT TRUNCATED AT 250 WORDS)

原文English
頁(從 - 到)99-104
頁數6
期刊Acta anaesthesiologica Sinica
32
發行號2
出版狀態Published - 1994 六月 1

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

指紋 深入研究「Propofol does not reduce infarct volume in rats undergoing permanent middle cerebral artery occlusion.」主題。共同形成了獨特的指紋。

引用此