Propranolol combined with dopamine has a synergistic action in intensifying and prolonging cutaneous analgesia in rats

Yu Wen Chen, Chong Chi Chiu, Yu Lei Wei, Ching-Hsia Hung, Jhi Joung Wang

研究成果: Article

9 引文 (Scopus)

摘要

Background The purpose of the experiment was to assess interactions of dopamine with propranolol as an infiltrative anesthetic. Methods After injecting the rats with four doses of drugs subcutaneously, the cutaneous analgesic effect of propranolol was compared with dopamine through the blockade of cutaneous trunci muscle reflex (CTMR) in response to local skin pinprick. Drug-drug interactions were examined via an isobolographic analysis. Results We demonstrated that the action of propranolol and dopamine was dose dependent to skin infiltrative analgesia. On the ED50 (50% effective dose) basis, the rank of drug potency was propranolol (11.3 [10.6-12.2] μmol) > dopamine (195 [188-205] μmol) (p < 0.001). At the equi-anesthetic doses (ED25, ED50, ED75), the block duration caused by dopamine was equal to that caused by propranolol. Coadministration of dopamine and propranolol exhibited a synergistic effect on infiltrative cutaneous analgesia. Conclusions The preclinical data showed that dopamine produced a lesser potency but a comparable duration of cutaneous analgesia compared to propranolol. Adding dopamine to propranolol potentiated and prolonged propranolol's cutaneous analgesic effect.

原文English
頁(從 - 到)1224-1229
頁數6
期刊Pharmacological Reports
67
發行號6
DOIs
出版狀態Published - 2015 十二月 1

指紋

Propranolol
Analgesia
Dopamine
Skin
Analgesics
Anesthetics
Pharmaceutical Preparations
Drug Interactions
Reflex
Muscles

All Science Journal Classification (ASJC) codes

  • Pharmacology

引用此文

Chen, Yu Wen ; Chiu, Chong Chi ; Wei, Yu Lei ; Hung, Ching-Hsia ; Wang, Jhi Joung. / Propranolol combined with dopamine has a synergistic action in intensifying and prolonging cutaneous analgesia in rats. 於: Pharmacological Reports. 2015 ; 卷 67, 編號 6. 頁 1224-1229.
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Propranolol combined with dopamine has a synergistic action in intensifying and prolonging cutaneous analgesia in rats. / Chen, Yu Wen; Chiu, Chong Chi; Wei, Yu Lei; Hung, Ching-Hsia; Wang, Jhi Joung.

於: Pharmacological Reports, 卷 67, 編號 6, 01.12.2015, p. 1224-1229.

研究成果: Article

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AU - Chiu, Chong Chi

AU - Wei, Yu Lei

AU - Hung, Ching-Hsia

AU - Wang, Jhi Joung

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background The purpose of the experiment was to assess interactions of dopamine with propranolol as an infiltrative anesthetic. Methods After injecting the rats with four doses of drugs subcutaneously, the cutaneous analgesic effect of propranolol was compared with dopamine through the blockade of cutaneous trunci muscle reflex (CTMR) in response to local skin pinprick. Drug-drug interactions were examined via an isobolographic analysis. Results We demonstrated that the action of propranolol and dopamine was dose dependent to skin infiltrative analgesia. On the ED50 (50% effective dose) basis, the rank of drug potency was propranolol (11.3 [10.6-12.2] μmol) > dopamine (195 [188-205] μmol) (p < 0.001). At the equi-anesthetic doses (ED25, ED50, ED75), the block duration caused by dopamine was equal to that caused by propranolol. Coadministration of dopamine and propranolol exhibited a synergistic effect on infiltrative cutaneous analgesia. Conclusions The preclinical data showed that dopamine produced a lesser potency but a comparable duration of cutaneous analgesia compared to propranolol. Adding dopamine to propranolol potentiated and prolonged propranolol's cutaneous analgesic effect.

AB - Background The purpose of the experiment was to assess interactions of dopamine with propranolol as an infiltrative anesthetic. Methods After injecting the rats with four doses of drugs subcutaneously, the cutaneous analgesic effect of propranolol was compared with dopamine through the blockade of cutaneous trunci muscle reflex (CTMR) in response to local skin pinprick. Drug-drug interactions were examined via an isobolographic analysis. Results We demonstrated that the action of propranolol and dopamine was dose dependent to skin infiltrative analgesia. On the ED50 (50% effective dose) basis, the rank of drug potency was propranolol (11.3 [10.6-12.2] μmol) > dopamine (195 [188-205] μmol) (p < 0.001). At the equi-anesthetic doses (ED25, ED50, ED75), the block duration caused by dopamine was equal to that caused by propranolol. Coadministration of dopamine and propranolol exhibited a synergistic effect on infiltrative cutaneous analgesia. Conclusions The preclinical data showed that dopamine produced a lesser potency but a comparable duration of cutaneous analgesia compared to propranolol. Adding dopamine to propranolol potentiated and prolonged propranolol's cutaneous analgesic effect.

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