Prostaglandin E2: The master of endometriosis?

Meng Hsing Wu, Chun Wun Lu, Pei Chin Chuang, Shaw Jenq Tsai

研究成果: Short survey

83 引文 斯高帕斯(Scopus)

摘要

Endometriosis is the primary cause of infertility in women, with a prevalence rate ranging from 5% to 10%. Women with endometriosis suffer from symptoms such as chronic pelvic pain, dysmenorrhea and dyspareunia, which significantly reduce the quality of life. Endometriosis is a polygenic disease with a complex, multifactorial etiology. The mechanism responsible for the initiation and development of this disease remains largely unknown. Prostaglandin E2 (PGE2), a versatile eicosanoid that exerts numerous physiological and pathological functions, has been implicated to play critical roles in the development of endometriosis. A growing body of evidence demonstrates that PGE2 regulates many pathophysiological processes including cell proliferation, antiapoptosis, immune suppression and angiogenesis during the development of endometriosis. This review focuses on recent advances in cellular and molecular mechanisms triggered by PGE 2 that contribute to the pathological processes of endometriosis.

原文English
頁(從 - 到)668-677
頁數10
期刊Experimental Biology and Medicine
235
發行號6
DOIs
出版狀態Published - 2010 六月 1

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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