Prostaglandin F receptor in the corpus luteum: Recent information on the gene, messenger ribonucleic acid, and protein

L. E. Anderson, Y. L. Wu, S. J. Tsai, M. C. Wiltbank

研究成果: Short survey同行評審

49 引文 斯高帕斯(Scopus)

摘要

The prostaglandin (PG) F receptor (FPr) in the corpus luteum is essential for maintaining normal reproductive cyclicity in many species. Activation of this seven-transmembrane spanning receptor at the end of the cycle leads to a decrease in progesterone and the demise of the corpus luteum (luteolysis). Recently, the gene structure of the FPr in three mammalian species has been elucidated; however, promoter regulation of the gene is still poorly understood. The FPr tuRNA is extremely low in steroidogenic follicular cells (theca or granulosa) but is expressed at high levels in the corpus luteum, particularly in the large luteal cells. Treatment with PGF decreased FPr mRNA expression in luteal cells in most species that have been studied. Key amino acids have been suggested to be critical for binding of FPr to PGF based on three-dimensional modeling and comparisons with other G-protein-coupled receptors. Moieties of the PGF molecule that are essential for binding or specificity of binding to the FPr have been identified by radioreceptor binding studies. In this article, recent information is reviewed on the structure of the FPr gene, regulation of luteal FPr mRNA, and receptor/ligand interaction requirements for the FPr protein.

原文English
頁(從 - 到)1041-1047
頁數7
期刊Biology of Reproduction
64
發行號4
DOIs
出版狀態Published - 2001

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Cell Biology

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