Protective effect of sesamol on the pulmonary inflammatory response and lung injury in endotoxemic rats

Pei Yi Chu, Se Ping Chien, Dur Zong Hsu, Ming Yie Liu

研究成果: Article同行評審

37 引文 斯高帕斯(Scopus)

摘要

We investigated the effect of sesamol on systemic lipopolysaccharide (LPS)-induced lung inflammation in rats. Sesamol decreased lung edema and injury, significantly decreased LPS-induced cell counts, protein concentration, tumor necrosis factor (TNF)-α, and nitrite levels in bronchoalveolar lavage fluid, and decreased the TNF-α, nitrite, and inducible nitric oxide synthase protein expression in lung tissue. Further, sesamol significantly inhibited LPS-induced TNF-α, nitrite, inducible nitric oxide synthase expression, and nuclear factor-κB activation levels in primary alveolar macrophages. We hypothesize that sesamol attenuates systemic LPS-induced lung inflammation by inhibiting the alveolar macrophage inflammatory response in rats.

原文English
頁(從 - 到)1821-1826
頁數6
期刊Food and Chemical Toxicology
48
發行號7
DOIs
出版狀態Published - 2010 七月

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

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