Protective effect of the apo ε2 allele in major depressive disorder in Taiwanese

P. L. Fan, C. D. Chen, W. T. Kao, B. C. Shu, F. W. Lung

研究成果: Article同行評審

23 引文 斯高帕斯(Scopus)


Objective: Major depression is an important comorbidity in Alzheimer's disease, which is definitely associated with the apolipoprotein E (apo E) polymorphism. The aim of this study was to explore the role of the different apo E polymorphisms in major depressive disorder (MDD) in a Taiwanese population. Method: We examined apo E genotypes in 273 Taiwanese patients with MDD and 429 healthy community controls, and compared their polymorphism distribution. Results: The allelic frequency of apo ε2 was significantly lower in patients with MDD than in the controls, whereas no significant difference in apo ε4 allelic frequency between these two groups was found. Conclusion: The apo ε4 allele was not associated with MDD in this study. However, the finding of a lower frequency of the apo ε2 allele in MDD could lead to the conclusion that the apo ε2 allele likely provides a protective effect against MDD in the Taiwanese population.

頁(從 - 到)48-53
期刊Acta Psychiatrica Scandinavica
出版狀態Published - 2006 一月 1

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

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