Prothymosin α enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis

Ai Li Shiau, Yen Lin Chen, Chen Yu Liao, Yen Sung Huang, Chao Liang Wu

研究成果: Article同行評審

41 引文 斯高帕斯(Scopus)

摘要

Previously, we showed that vaccination with the glycoprotein D (gD) gene of pseudorabies virus (PrV) delivered by Escherichia coli induced protective immune responses. In this study, we report that oral DNA vaccination with attenuated Salmonella choleraesuis carrying the PrV gD gene conferred protective immunity in mice against PrV. Moreover, co-delivery of the prothymosin α gene carried by S. choleraesuis enhanced the vaccine efficacy. Our results thus demonstrate for the first time, to our knowledge, the effectiveness of oral DNA vaccination using S. choleraesuis as a delivery vehicle and the potential usefulness of prothymosin α as a DNA vaccine adjuvant.

原文English
頁(從 - 到)3947-3956
頁數10
期刊Vaccine
19
發行號28-29
DOIs
出版狀態Published - 2001 7月 16

All Science Journal Classification (ASJC) codes

  • 分子醫學
  • 一般免疫學和微生物學
  • 一般獸醫學
  • 公共衛生、環境和職業健康
  • 傳染性疾病

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