Prothymosin α promotes cell proliferation in NIH3T3 cells

Chao-Liang Wu, Ai-Li Shiau, Chein Sheng Lin

研究成果: Article同行評審

47 引文 斯高帕斯(Scopus)

摘要

Thymic hormones have immunomodulatory effects on T cells and hence have been used clinically to restore the immunity of immunodeficient patients as well as to enhance the cellular immunity of cancer patients. Prothymosin α, which is a member of the thymic hormone family, has recently been suggested to act as a nuclear protein participating in the stimulation of cell proliferation. To characterize the biological activities of prothymosin a in vitro, we established NIH3T3 cell transformants that constitutively express higher prothymosin a protein and its mRNA compared with the wild-type counterpart. Cells that overexpressed prothymosin a increased the proliferative activity assayed by the [3H]-thymidine incorporation or by the cell cycle analysis with the fluorescent-activate cell sorter. The results provide direct evidence that prothymosin a plays a role in cell proliferation by shortening the duration of the G1 phase.

原文English
頁(從 - 到)2091-2101
頁數11
期刊Life Sciences
61
發行號21
DOIs
出版狀態Published - 1997 10月 17

All Science Journal Classification (ASJC) codes

  • 一般生物化學,遺傳學和分子生物學
  • 藥理學、毒理學和藥劑學 (全部)

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