Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Liu Chun Wang, Pei Yu Chiou, Ya Ping Hsu, Chin Lai Lee, Chih Hsuan Hung, Yi Hsuan Wu, Wen Jyun Wang, Gia Ling Hsieh, Ying Chi Chen, Li Chan Chang, Wen Pin Su, Divinah Manoharan, Min Chiao Liao, Suresh Thangudu, Wei Peng Li, Chia Hao Su, Hong Kang Tian, Chen Sheng Yeh

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H2O2 → ‧OH for tumoral therapy. Unfortunately, H2O2 is often taken from the limited endogenous supply of H2O2 in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H2O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe3+-N ≡ C-Fe2+ composition through the proposed proton-induced metal replacement reactions. Surprisingly, both the CFPB nanocubes and nanoframes provide for the self-supply of O2, H2O2, and ‧OH from H2O, with the nanoframe outperforming in the production of ‧OH. Simulation analysis indicates separated active sites in catalyzation of water oxidation, oxygen reduction, and Fenton-like reactions from CFPB. The liposome-covered CFPB nanoframes prepared for controllable water-driven CDT for male tumoral mice treatments.

原文English
文章編號4709
期刊Nature communications
14
發行號1
DOIs
出版狀態Published - 2023 12月

All Science Journal Classification (ASJC) codes

  • 一般化學
  • 一般生物化學,遺傳學和分子生物學
  • 一般物理與天文學

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