Quantifying effect of onabotulinum toxin a on passive muscle stiffness in children with cerebral palsy using ultrasound shear wave elastography

Joline E. Brandenburg, Sarah F. Eby, Pengfei Song, William R. Bamlet, Gary C. Sieck, Kai Nan An

研究成果: Article同行評審

33 引文 斯高帕斯(Scopus)

摘要

Objective A pilot study was conducted to longitudinally quantify effect of onabotulinum toxin A (BoNT-A) on passive muscle properties in children with cerebral palsy using ultrasound shear wave elastography. Design This was a prospective longitudinal cohort study. Results Between 1 and 3 mos post-BoNT-A, a significant improvement in the shear modulus of the lateral gastrocnemius was found at 10-degrees plantar flexion (PF) (-7.57 [-10.98, -5.07], P = 0.02) and 0-degrees PF (-14.74 [-18.21, -9.38], P = 0.03). There was a notable, but nonsignificant, difference in shear modulus at 20-degrees PF, 10-degrees PF, and 0-degrees PF between pre-BoNT-A and 1 mo post-BoNT-A. Pre-BoNT-A shear modulus was not significantly different from 3 mos post-BoNT-A at all foot positions. No significant differences in ankle passive range of motion or spasticity were found. Conclusion Despite no significant change in ankle range of motion or spasticity, shear wave elastography was able to detect a difference in lateral gastrocnemius passive muscle properties in children with cerebral palsy after BoNT-A injections. The difference in passive muscle properties resolved by 3 mos post-BoNT-A.

原文English
頁(從 - 到)500-506
頁數7
期刊American Journal of Physical Medicine and Rehabilitation
97
發行號7
DOIs
出版狀態Published - 2018 7月 1

All Science Journal Classification (ASJC) codes

  • 物理治療、運動療法和康復
  • 復健

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