摘要
Characterizing the viscoelastic properties of thin-layer tissues with micro-level thickness has long remained challenging. Recently, several micro-elastography techniques have been developed to improve the spatial resolution. However, most of these techniques have not considered the medium boundary conditions when evaluating the viscoelastic properties of thin-layer tissues such as arteries and corneas; this might lead to estimation bias or errors. This paper aims to integrate the Lamb wave model with our previously developed ultrasonic micro-elastography imaging system for obtaining accurate viscoelastic properties in thin-layer tissues. A 4.5-MHz ring transducer was used to generate an acoustic radiation force for inducing tissue displacements to produce guided wave, and the wave propagation was detected using a confocally aligned 40-MHz needle transducer. The phase velocity and attenuation were obtained from k-space by both the impulse and the harmonic methods. The measured phase velocity was fit using the Lamb wave model with the Kelvin-Voigt model. Phantom experiments were conducted using 7% and 12% gelatin and 1.5% agar phantoms with different thicknesses (2, 3, and 4 mm). Biological experiments were performed on porcine cornea and rabbit carotid artery ex vivo. Thin-layer phantoms with different thicknesses were confirmed to have the same elasticity; this was consistent with the estimates of bulk phantoms from mechanical tests and the shear wave rheological model. The trend of the measured attenuations was also confirmed with the viscosity results obtained using the Lamb wave model. Through the impulse and harmonic methods, the shear viscoelasticity values were estimated to be 8.2 kPa for 0.9 Pa s and 9.6 kPa for 0.8 Pa s in the cornea and 27.9 kPa for 0.1 Pa s and 26.5 kPa for 0.1 Pa s in the artery.
| 原文 | English |
|---|---|
| 文章編號 | 8327620 |
| 頁（從 - 到） | 1887-1898 |
| 頁數 | 12 |
| 期刊 | IEEE Transactions on Medical Imaging |
| 卷 | 37 |
| 發行號 | 8 |
| DOIs | |
| 出版狀態 | Published - 2018 八月 |
指紋
All Science Journal Classification (ASJC) codes
- Software
- Radiological and Ultrasound Technology
- Computer Science Applications
- Electrical and Electronic Engineering
引用此文
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Quantitative assessment of thin-layer tissue viscoelastic properties using ultrasonic micro-elastography with lamb wave model. / Shih, Cho Chiang; Qian, Xuejun; Ma, Teng; Han, Zhaolong; Huang, Chih Chung; Zhou, Qifa; Shung, K. Kirk.
於: IEEE Transactions on Medical Imaging, 卷 37, 編號 8, 8327620, 08.2018, p. 1887-1898.研究成果: Article
TY - JOUR
T1 - Quantitative assessment of thin-layer tissue viscoelastic properties using ultrasonic micro-elastography with lamb wave model
AU - Shih, Cho Chiang
AU - Qian, Xuejun
AU - Ma, Teng
AU - Han, Zhaolong
AU - Huang, Chih Chung
AU - Zhou, Qifa
AU - Shung, K. Kirk
PY - 2018/8
Y1 - 2018/8
N2 - Characterizing the viscoelastic properties of thin-layer tissues with micro-level thickness has long remained challenging. Recently, several micro-elastography techniques have been developed to improve the spatial resolution. However, most of these techniques have not considered the medium boundary conditions when evaluating the viscoelastic properties of thin-layer tissues such as arteries and corneas; this might lead to estimation bias or errors. This paper aims to integrate the Lamb wave model with our previously developed ultrasonic micro-elastography imaging system for obtaining accurate viscoelastic properties in thin-layer tissues. A 4.5-MHz ring transducer was used to generate an acoustic radiation force for inducing tissue displacements to produce guided wave, and the wave propagation was detected using a confocally aligned 40-MHz needle transducer. The phase velocity and attenuation were obtained from k-space by both the impulse and the harmonic methods. The measured phase velocity was fit using the Lamb wave model with the Kelvin-Voigt model. Phantom experiments were conducted using 7% and 12% gelatin and 1.5% agar phantoms with different thicknesses (2, 3, and 4 mm). Biological experiments were performed on porcine cornea and rabbit carotid artery ex vivo. Thin-layer phantoms with different thicknesses were confirmed to have the same elasticity; this was consistent with the estimates of bulk phantoms from mechanical tests and the shear wave rheological model. The trend of the measured attenuations was also confirmed with the viscosity results obtained using the Lamb wave model. Through the impulse and harmonic methods, the shear viscoelasticity values were estimated to be 8.2 kPa for 0.9 Pa s and 9.6 kPa for 0.8 Pa s in the cornea and 27.9 kPa for 0.1 Pa s and 26.5 kPa for 0.1 Pa s in the artery.
AB - Characterizing the viscoelastic properties of thin-layer tissues with micro-level thickness has long remained challenging. Recently, several micro-elastography techniques have been developed to improve the spatial resolution. However, most of these techniques have not considered the medium boundary conditions when evaluating the viscoelastic properties of thin-layer tissues such as arteries and corneas; this might lead to estimation bias or errors. This paper aims to integrate the Lamb wave model with our previously developed ultrasonic micro-elastography imaging system for obtaining accurate viscoelastic properties in thin-layer tissues. A 4.5-MHz ring transducer was used to generate an acoustic radiation force for inducing tissue displacements to produce guided wave, and the wave propagation was detected using a confocally aligned 40-MHz needle transducer. The phase velocity and attenuation were obtained from k-space by both the impulse and the harmonic methods. The measured phase velocity was fit using the Lamb wave model with the Kelvin-Voigt model. Phantom experiments were conducted using 7% and 12% gelatin and 1.5% agar phantoms with different thicknesses (2, 3, and 4 mm). Biological experiments were performed on porcine cornea and rabbit carotid artery ex vivo. Thin-layer phantoms with different thicknesses were confirmed to have the same elasticity; this was consistent with the estimates of bulk phantoms from mechanical tests and the shear wave rheological model. The trend of the measured attenuations was also confirmed with the viscosity results obtained using the Lamb wave model. Through the impulse and harmonic methods, the shear viscoelasticity values were estimated to be 8.2 kPa for 0.9 Pa s and 9.6 kPa for 0.8 Pa s in the cornea and 27.9 kPa for 0.1 Pa s and 26.5 kPa for 0.1 Pa s in the artery.
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U2 - 10.1109/TMI.2018.2820157
DO - 10.1109/TMI.2018.2820157
M3 - Article
C2 - 29993652
AN - SCOPUS:85044788045
VL - 37
SP - 1887
EP - 1898
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
SN - 0278-0062
IS - 8
M1 - 8327620
ER -