Radical-initiated cyclization as a key step for the synthesis of oxoprotoberberine alkaloids

Chih Shone Lee, Tsung Ching Yu, Jian Wen Luo, Yen Yao Cheng, Che Ping Chuang

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)

摘要

The oxoprotoberberine alkaloids 1a-d have been synthesized efficiently from the enamide derivatives 2a-d by a radical-initiated cyclization reaction utilizing n-Bu3SnH/AIBN and CuCl. The enamide derivatives 2a-d were prepared from phenylethylamine analogues 5a-b, followed by acylation with acetic anhydride, Bischler-Napieralski cyclization with POCl3 and benzoylation with the corresponding bromobenzoyl chloride, respectively.

原文English
頁(從 - 到)4558-4562
頁數5
期刊Tetrahedron Letters
50
發行號31
DOIs
出版狀態Published - 2009 八月 5

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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