Raloxifene versus continuous combined estrogen/progestin therapy: Densitometric and biochemical effects in healthy postmenopausal Taiwanese women

K. S. Tsai, M. L. Yen, H. A. Pan, M. H. Wu, W. C. Cheng, S. H.J. Hsu, B. L. Yen, K. E. Huang

研究成果: Article同行評審

25 引文 斯高帕斯(Scopus)

摘要

We treated 116 healthy postmenopausal women (age 47-66 years, mean 57 years) in Taiwan with either raloxifene (RLX) 60 mg (n = 92) or 0.625 mg conjugated equine estrogen plus 5 mg medroxyprogesterone acetate (CCEP, n = 24) daily for 12 months in a randomized, double-masked, active-controlled fashion. The results showed that both regimens increased bone mineral density (BMD) at hip bip sites (means: RLX 2.5-4.9%, CCEP 4.6-7.9%, all p < 0.005 compared with baseline), and the difference between the two regimens was not significant. The spinal BMD increased significantly in both groups (1.4% with RLX and 6.0% with CCEP, both p < 0.01), and more with CCEP (p < 0.003). Osteocalcin levels and urinary type I collagen C-telopeptide/creatinine ratios decreased significantly in both regimens, but the decreases were significantly larger with CCEP. Compared with baseline, both RLX and CCEP decreased the total cholesterol (median 4.9% and 8.6% respectively, p < 0.001) and LDL-cholesterol (median 11% and 19% respectively, p < 0.001), and increased HDL-cholesterol (median 8.6% and 10.7% respectively, p < 0.01). Both regimens increased triglyceride levels (median 3.2% and 18.9% respectively, both p < 0.05), although to a lesser extent with RLX than with CCEP (p < 0.05). Only 3 subjects (3.3%) reported vaginal bleeding in the RLX group, as compared with 31% (7/22) with CCEP (p < 0.05). We conclude that in healthy, postmenopausal Taiwanese women, RLX 60 mg given daily has favorable results in BMD, bone turnover and serum lipids, although the dosage we used showed a potency less than that of conventional CCEP.

原文English
頁(從 - 到)1020-1025
頁數6
期刊Osteoporosis International
12
發行號12
DOIs
出版狀態Published - 2001

All Science Journal Classification (ASJC) codes

  • 內分泌學、糖尿病和代謝

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