Rapid engraftment of mast cells of donor origin in a case of acute myeloid leukemia with mast cell leukemia after allogeneic stem cell transplantation

T. Y. Chen, J. S. Chen, W. T. Huang, W. C. Su, C. J. Tsao

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

Mastocytosis is a rare disease characterized by an abnormal increase of mast cells in tissues. We report a case of acute myeloid leukemia (AML) with t(8;21) and mast cell leukemia (MCL) in which the mastocytosis persisted after standard chemotherapy and allogeneic stem cell transplantation, although the myeloid leukemia achieved molecular complete remission soon after induction chemotherapy. Donor-type mast cells were noted on d31 after transplant. No c-kit mutation was found before or after the transplant. This represents the first reported case in which rapid engraftment of mast cells of donor origin was documented. Thus, the possibility that the mast cell originates from a common myeloid precursor cell may be questioned and a reactive process should be considered in some cases of systemic mastocytosis.

原文English
頁(從 - 到)111-114
頁數4
期刊Bone Marrow Transplantation
32
發行號1
DOIs
出版狀態Published - 2003 七月

All Science Journal Classification (ASJC) codes

  • 血液學
  • 移植

指紋

深入研究「Rapid engraftment of mast cells of donor origin in a case of acute myeloid leukemia with mast cell leukemia after allogeneic stem cell transplantation」主題。共同形成了獨特的指紋。

引用此