Rapid leptin elevation after initiation of olanzapine?

Hsuan Chi Wang, Po See Chen, I. Hui Lee, Yen Kuang Yang, Tzung Lieh Yeh, Ru Band Lu

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

Weight gain is a common adverse effect associated with olanzapine treatment. Another side effect of olanzapine treatment is a significant increase in circulating leptin levels. This preliminary study monitored the changes in leptin levels for 2 weeks after olanzapine treatment had been initiated. The relationship between the changes in circulating leptin levels and alterations in body weight in 9 patients with schizophrenia who received olanzapine was examined. The results showed that olanzapine may cause a surge in circulating leptin levels before weight gain is manifested. Moreover, higher pretreatment circulating leptin levels predicted lower weight gains after olanzapine treatments (r = -0.93; p < 0.05) after controlling for the effect of sex.

原文English
頁(從 - 到)182-185
頁數4
期刊Neuropsychobiology
54
發行號3
DOIs
出版狀態Published - 2007 三月

All Science Journal Classification (ASJC) codes

  • 神經心理學與生理心理學
  • 精神病學和心理健康
  • 生物精神病學

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