摘要
Weight gain is a common adverse effect associated with olanzapine treatment. Another side effect of olanzapine treatment is a significant increase in circulating leptin levels. This preliminary study monitored the changes in leptin levels for 2 weeks after olanzapine treatment had been initiated. The relationship between the changes in circulating leptin levels and alterations in body weight in 9 patients with schizophrenia who received olanzapine was examined. The results showed that olanzapine may cause a surge in circulating leptin levels before weight gain is manifested. Moreover, higher pretreatment circulating leptin levels predicted lower weight gains after olanzapine treatments (r = -0.93; p < 0.05) after controlling for the effect of sex.
原文 | English |
---|---|
頁(從 - 到) | 182-185 |
頁數 | 4 |
期刊 | Neuropsychobiology |
卷 | 54 |
發行號 | 3 |
DOIs | |
出版狀態 | Published - 2007 3月 |
All Science Journal Classification (ASJC) codes
- 神經心理學與生理心理學
- 精神病學和心理健康
- 生物精神病學