Rapid microwell prototyping, generation of 3D multicellular cancer aggregates, and emt drug screening

Ting Yuan Tu, Wei Sun, Weng Kung Peng, Zhe Wang, Ruby Y.J. Huang, Paul T. Matsudaira, Jean Paul Thiery, Roger D. Kamm

研究成果: Conference contribution

摘要

This work presents a microwell prototyping technique for generating multicellular cancer aggregates in suspension culture for epithelial- mesenchymal-transition (EMT) drug screening. Microwell and aggregate size and geometry were examined in PMMA, PDMS, polystyrene materials materials. Retrieved aggregates were further studied in terms of cell dispersion through drug screening, to identify the effective drug dosage for the inhibition of EMT. Two distinct cell phenotypic behaviors were discovered from Low-attachment-dish- and microwell-generated aggregates under different conditions. Future studies of the two types of aggregates may contribute to the understanding of cancer metastasis.

原文English
主出版物標題15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
頁面82-84
頁數3
出版狀態Published - 2011
事件15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
持續時間: 2011 十月 22011 十月 6

出版系列

名字15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
1

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
國家/地區United States
城市Seattle, WA
期間11-10-0211-10-06

All Science Journal Classification (ASJC) codes

  • 控制與系統工程

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