Rapid movement of axonal neurofilaments interrupted by prolonged pauses

Lei Wang, Chung Liang Ho, Dongming Sun, Ronald K.H. Liem, Anthony Brown

研究成果: Article同行評審

261 引文 斯高帕斯(Scopus)

摘要

Axonal cytoskeletal and cytosolic proteins are synthesized in the neuronal cell body and transported along axons by slow axonal transport, but attempts to observe this movement directly in living cells have yielded conflicting results. Here we report the direct observation of the axonal transport of neurofilament protein tagged with green fluorescent protein in cultured nerve cells. Live-cell imaging of naturally occurring gaps in the axonal neurofilament array reveals rapid, intermittent and highly asynchronous movement of fluorescent neurofilaments. The movement is bidirectional, but predominantly anterograde. Our data indicate that the slow rate of slow axonal transport may be the result of rapid movements interrupted by prolonged pauses.

原文English
頁(從 - 到)137-141
頁數5
期刊Nature Cell Biology
2
發行號3
DOIs
出版狀態Published - 2000

All Science Journal Classification (ASJC) codes

  • 細胞生物學

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