Rapidly fatal outcome of bacteremic Klebsiella pneumoniae pneumonia in alcoholics

G. M. Jong, T. R. Hsiue, C. R. Chen, H. Y. Chang, C. W. Chen

研究成果: Article同行評審

123 引文 斯高帕斯(Scopus)


Twenty-eight alcoholic patients with community-acquired pneumonia who were admitted to a referral medical center during a 3-year period were reviewed. All were men and with few exceptions were heavy smokers. The overall mortality was 64.3%. The most dramatic group was that of 11 patients (39.3%) with bacteremic Klebsiella pneumoniae pneumonia (BKPP), which had high mortality rate (100%), short onset of illness before hospital admission (42.6 ± 8.2 h, mean ± SD), and short survival time after the admission (24.6 ± 7.9 h). All these 11 patients needed intensive care unit (ICU) management and ventilatory support. Arterial blood gas values showed marked hypoxemia and metabolic acidosis in most of these 11 patients, and presence of shock at arrival in the hospital was noted in 8 patients. Acute renal failure and disseminated intravascular coagulation developed in six patients. Chest radiographs showed pleural effusion and radiographic spread in nearly 50% of patients. Combination chemotherapy consisting of one aminoglycoside and one second- or third-generation cephalosporin was initiated in all patients. The rapidly fatal outcome of these 11 patients with BKPP despite management with adequate antibiotics and intensive care indicated the fulminant nature of this disease. High virulence of the microorganism, altered immune response, and increased susceptibility to infection may all have contributed to the fulminancy in this group of patients. The disease continues to present many difficulties in management.

頁(從 - 到)214-217
出版狀態Published - 1995 一月 1

All Science Journal Classification (ASJC) codes

  • 肺和呼吸系統醫學
  • 重症監護和重症監護醫學
  • 心臟病學與心血管醫學


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