Rapidly in situ forming hydrophobically-modified chitosan hydrogels via pH-responsive nanostructure transformation

Ya Ling Chiu, Mei-Chin Chen, Chun Yu Chen, Po Wei Lee, Fwu Long Mi, U. Ser Jeng, Hsin Lung Chen, Hsing Wen Sung

研究成果: Article同行評審

30 引文 斯高帕斯(Scopus)

摘要

A pH-responsive hydrogel targeted for various biomedical applications has been developed using a naturally-abundant biopolymer, chitosan, with controlled grafting of hydrophobic side chains. The rapid hydrogelation is driven by a transformation of the nanostructure of the side-chain aggregates from local micelles to interconnected nanodomains in a sponge phase due to the dominance of hydrophobic interaction near physiological pH.

原文English
頁(從 - 到)962-965
頁數4
期刊Soft Matter
5
發行號5
DOIs
出版狀態Published - 2009 三月 5

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 凝聚態物理學

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