Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

Shio Shin Jean; Wen Sen Lee; Kwok Woon Yu; Chun Hsing Liao; Chin Wang Hsu; Feng Yi Chang; Wen Chien Ko; Ray Jade Chen; Jiunn Jong Wu; Yen Hsu Chen; Yao Shen Chen; Jien Wei Liu; Min Chi Lu; Carlos Lam; Cheng Yi Liu; Po Ren Hsueh

doi:10.1016/j.jmii.2014.12.008

Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

Shio Shin Jean, Wen Sen Lee, Kwok Woon Yu, Chun Hsing Liao, Chin Wang Hsu, Feng Yi Chang, Wen Chien Ko, Ray Jade Chen, Jiunn Jong Wu, Yen Hsu Chen, Yao Shen Chen, Jien Wei Liu, Min Chi Lu, Carlos Lam, Cheng Yi Liu, Po Ren Hsueh

內科學科

研究成果: Article › 同行評審

20 引文斯高帕斯（Scopus）

摘要

Background Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results Colistin showed excellent in vitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73–77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC₉₀ value was 4 μg/mL for methicillin-resistant Staphylococcus aureus and 16 μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.

原文	English
頁（從 - 到）	969-976
頁數	8
期刊	Journal of Microbiology, Immunology and Infection
卷	49
發行號	6
DOIs	https://doi.org/10.1016/j.jmii.2014.12.008
出版狀態	Published - 2016 12月 1

All Science Journal Classification (ASJC) codes

免疫學和過敏
一般免疫學和微生物學
微生物學（醫學）
傳染性疾病

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Jean, S. S., Lee, W. S., Yu, K. W., Liao, C. H., Hsu, C. W., Chang, F. Y., Ko, W. C., Chen, R. J., Wu, J. J., Chen, Y. H., Chen, Y. S., Liu, J. W., Lu, M. C., Lam, C., Liu, C. Y., & Hsueh, P. R. (2016). Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). Journal of Microbiology, Immunology and Infection, 49(6), 969-976. https://doi.org/10.1016/j.jmii.2014.12.008

Jean, Shio Shin ; Lee, Wen Sen ; Yu, Kwok Woon 等. / Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007 : Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). 於: Journal of Microbiology, Immunology and Infection. 2016 ; 卷 49, 編號 6. 頁 969-976.

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title = "Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)",

abstract = "Background Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results Colistin showed excellent in vitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73–77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4 μg/mL for methicillin-resistant Staphylococcus aureus and 16 μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.",

author = "Jean, {Shio Shin} and Lee, {Wen Sen} and Yu, {Kwok Woon} and Liao, {Chun Hsing} and Hsu, {Chin Wang} and Chang, {Feng Yi} and Ko, {Wen Chien} and Chen, {Ray Jade} and Wu, {Jiunn Jong} and Chen, {Yen Hsu} and Chen, {Yao Shen} and Liu, {Jien Wei} and Lu, {Min Chi} and Carlos Lam and Liu, {Cheng Yi} and Hsueh, {Po Ren}",

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language = "English",

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Jean, SS, Lee, WS, Yu, KW, Liao, CH, Hsu, CW, Chang, FY, Ko, WC, Chen, RJ, Wu, JJ, Chen, YH, Chen, YS, Liu, JW, Lu, MC, Lam, C, Liu, CY & Hsueh, PR 2016, 'Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)', Journal of Microbiology, Immunology and Infection, 卷 49, 編號 6, 頁 969-976. https://doi.org/10.1016/j.jmii.2014.12.008

Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). / Jean, Shio Shin; Lee, Wen Sen; Yu, Kwok Woon 等.
於: Journal of Microbiology, Immunology and Infection, 卷 49, 編號 6, 01.12.2016, p. 969-976.

研究成果: Article › 同行評審

TY - JOUR

T1 - Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007

T2 - Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

AU - Jean, Shio Shin

AU - Lee, Wen Sen

AU - Yu, Kwok Woon

AU - Liao, Chun Hsing

AU - Hsu, Chin Wang

AU - Chang, Feng Yi

AU - Ko, Wen Chien

AU - Chen, Ray Jade

AU - Wu, Jiunn Jong

AU - Chen, Yen Hsu

AU - Chen, Yao Shen

AU - Liu, Jien Wei

AU - Lu, Min Chi

AU - Lam, Carlos

AU - Liu, Cheng Yi

AU - Hsueh, Po Ren

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results Colistin showed excellent in vitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73–77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4 μg/mL for methicillin-resistant Staphylococcus aureus and 16 μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.

AB - Background Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results Colistin showed excellent in vitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73–77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4 μg/mL for methicillin-resistant Staphylococcus aureus and 16 μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.

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DO - 10.1016/j.jmii.2014.12.008

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AN - SCOPUS:84922735991

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Jean SS, Lee WS, Yu KW, Liao CH, Hsu CW, Chang FY 等. Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). Journal of Microbiology, Immunology and Infection. 2016 12月 1;49(6):969-976. doi: 10.1016/j.jmii.2014.12.008