Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study

Hsin I. Shihid, Chia Yu Chi, Pei Fang Tsai, Yu Ping Wang, Yu Wen Chien

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Previous studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limita-tions of these studies. A population-based cohort study was conducted using national health databases in Taiwan and included 63,814 newly diagnosed, laboratory-confirmed dengue patients between 2002 and 2015 and 1:4 controls (n = 255,256) matched by age, sex, area of residence and symptom onset time. Multivariate Cox proportional hazard regression mod-els were used to investigate the risk of autoimmune diseases after dengue infection. Den-gue patients had a slightly higher risk of overall autoimmune diseases than non-dengue controls (aHR 1.16; P = 0.0002). Stratified analyses by specific autoimmune diseases showed that only autoimmune encephalomyelitis remained statistically significant after Bon-ferroni correction for multiple testing (aHR 2.72; P < 0.0001). Sixteen (0.025%) dengue patients and no (0%) controls developed autoimmune encephalomyelitis in the first month of follow-up (HR >9999, P < 0.0001), but the risk between groups was not significantly different thereafter. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not associated with other autoimmune diseases.

原文English
文章編號e0011127
期刊PLoS neglected tropical diseases
17
發行號3
DOIs
出版狀態Published - 2023 3月

All Science Journal Classification (ASJC) codes

  • 公共衛生、環境和職業健康
  • 傳染性疾病

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