Recent advances in natural anti-obesity compounds and derivatives based on in vivo evidence: A mini-review

Yi Han Chang, Hsin Yi Hung

研究成果: Review article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Obesity is not only viewed as a chronic aggressive disorder but is also associated with an increased risk for various diseases. Nonetheless, new anti-obesity drugs are an urgent need since few pharmacological choices are available on the market. Natural compounds have served as templates for drug discovery, whereas modified molecules from the leads identified based on in vitro models often reveal noncorresponding bioactivity between in vitro and in vivo studies. Therefore, to provide inspiration for the exploration of innovative anti-obesity agents, recent discoveries of natural anti-obesity compounds with in vivo evidence have been summarized according to their chemical structures, and the comparable efficacy of these compounds is categorized using animal models. In addition, several synthetic derivatives optimized from the phytochemicals are also provided to discuss medicinal chemistry achievements guided by natural sources.

原文English
文章編號114405
期刊European Journal of Medicinal Chemistry
237
DOIs
出版狀態Published - 2022 7月 5

All Science Journal Classification (ASJC) codes

  • 藥理
  • 藥物發現
  • 有機化學

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