Reduction of RNA A-to-I editing in Drosophila acclimated to heat shock

Joel Stocker, Hurng Wern Huang, Hong Ming Wang, Hsueh Wei Chang, Chien Chih Chiu, Chung Lung Cho, Chao Neng Tseng

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

Although an increasing number of RNA adenosine-to-inosine (A-to-I) editing sites are being discovered, how the editing frequencies of these sites are modulated to fine-tune protein function in adaptive responses is not well understood. A previous study screening for heat tolerance in Drosophila mutants discovered a hypnos-2 mutant strain that was later found to be defective in dADAR, the Drosophila gene encoding the A-to-I editing enzyme. This supports the hypothesis that cells and organisms respond to stressful environments by ADAR (adenosine deaminase acting on RNA)-mediated RNA editing. Here, we investigated changes in the RNA A-to-I editing frequencies of 30 Drosophila nervous system targets in response to heat shock, a stress acclimatization that requires the dADAR function. To our surprise, most of these nervous system editing targets showed reduced editing. Our results suggest that a change in RNA editing pattern is a mechanism by which organisms acclimate to drastic environmental change. However, how RNA editing confers heat resistance is more complicated and requires further investigation.

原文English
頁(從 - 到)478-483
頁數6
期刊Kaohsiung Journal of Medical Sciences
29
發行號9
DOIs
出版狀態Published - 2013 九月

All Science Journal Classification (ASJC) codes

  • 醫藥 (全部)

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