Reemergence of enterovirus 71 in 2008 in Taiwan: Dynamics of genetic and antigenic evolution from 1998 to 2008

Sheng Wen Huang, Yun Wei Hsu, Derek J. Smith, David Kiang, Huey Pin Tsai, Kuei Hsiang Lin, Shih-Min Wang, Ching-Chuan Liu, Ih Jen Su, Jen-Ren Wang

研究成果: Article

149 引文 (Scopus)

摘要

In recent years, enterovirus 71 (EV71) has been a cause of numerous outbreaks of hand-foot-and-mouth disease, with severe neurological complications in the Asia-Pacific region. The reemergence in Taiwan of EV71 genotype B5 in 2008 resulted in the largest outbreak of EV71 in Taiwan in the past 11 years. Phylogenetic analyses indicated that dominant genotype changes from B to C or C to B occurred at least three times between 1986 and 2008. Furthermore, antigenic cartography of EV71 by using neutralization tests revealed that the reemerging EV71 genotype B5 strains formed a separate cluster which was antigenically distinct from the B4 and C genotypes. Moreover, analyses of full-length genomic sequences of EV71 circulating in Taiwan during this period showed the occurrence of intra- and interserotypic recombination. Therefore, continuous surveillance of EV71 including the monitoring of genetic evolution and antigenic changes is recommended and may contribute to the development of a vaccine for EV71.

原文English
頁(從 - 到)3653-3662
頁數10
期刊Journal of Clinical Microbiology
47
發行號11
DOIs
出版狀態Published - 2009 十一月 1

指紋

Molecular Evolution
Enterovirus
Taiwan
Genotype
Disease Outbreaks
Hand, Foot and Mouth Disease
Neutralization Tests
Genetic Recombination
Vaccines

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

引用此文

Huang, Sheng Wen ; Hsu, Yun Wei ; Smith, Derek J. ; Kiang, David ; Tsai, Huey Pin ; Lin, Kuei Hsiang ; Wang, Shih-Min ; Liu, Ching-Chuan ; Su, Ih Jen ; Wang, Jen-Ren. / Reemergence of enterovirus 71 in 2008 in Taiwan : Dynamics of genetic and antigenic evolution from 1998 to 2008. 於: Journal of Clinical Microbiology. 2009 ; 卷 47, 編號 11. 頁 3653-3662.
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Reemergence of enterovirus 71 in 2008 in Taiwan : Dynamics of genetic and antigenic evolution from 1998 to 2008. / Huang, Sheng Wen; Hsu, Yun Wei; Smith, Derek J.; Kiang, David; Tsai, Huey Pin; Lin, Kuei Hsiang; Wang, Shih-Min; Liu, Ching-Chuan; Su, Ih Jen; Wang, Jen-Ren.

於: Journal of Clinical Microbiology, 卷 47, 編號 11, 01.11.2009, p. 3653-3662.

研究成果: Article

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